(Q41671770)

6 October 2017

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title

Calcium sensitisers: mechanisms of action and potential usefulness as inotropes (English)

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6 October 2017

Lee JA

1

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6 October 2017

Allen DG

series ordinal

2

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6 October 2017

language of work or name

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1 October 1997

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6 October 2017

published in

Cardiovascular Research

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6 October 2017

volume

36

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6 October 2017

issue

1

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6 October 2017

page(s)

10-20

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Epidemiologic patterns, clinical evaluation, and long-term prognosis in chronic congestive heart failure

6 October 2017

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Survival after the onset of congestive heart failure in Framingham Heart Study subjects

7 January 2021

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Pathophysiology of chronic heart failure

7 January 2021

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Medical advances in the treatment of congestive heart failure

7 January 2021

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Pathophysiology and treatment of congestive heart failure

7 January 2021

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7 January 2021

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Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study

7 January 2021

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A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure

7 January 2021

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Effects of vesnarinone on morbidity and mortality in patients with heart failure. Vesnarinone Study Group

7 January 2021

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The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

7 January 2021

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Treatment of severe heart failure: quantity or quality of life? A trial of enoximone. Enoximone Investigators

7 January 2021

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The search for the ideal positive inotropic agent

7 January 2021

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Evidence for cross-bridge attachment in relaxed muscle at low ionic strength

7 January 2021

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An X-ray diffraction study of the cross-circulated canine heart

7 January 2021

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Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction

7 January 2021

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Relationship between force and intracellular [Ca2+] in tetanized mammalian heart muscle

7 January 2021

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Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle

7 January 2021

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Activation of thin-filament-regulated muscle by calcium ion: considerations based on nearest-neighbor lattice statistics

7 January 2021

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Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998

7 January 2021

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Calcium transients in mammalian ventricular muscle

7 January 2021

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The relationship between intracellular calcium and contraction in calcium-overloaded ferret papillary muscles

7 January 2021

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Spontaneous Ca2+ release from the sarcoplasmic reticulum limits Ca2+-dependent twitch potentiation in individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium

7 January 2021

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Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart

7 January 2021

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Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation

7 January 2021

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Diastolic, systolic and sarcoplasmic reticulum [Ca2+] during inotropic interventions in isolated rat myocytes

7 January 2021

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Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat

7 January 2021

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Stimulation of Ca++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent

7 January 2021

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Effect of isomazole on the responsiveness to calcium of the contractile elements in skinned cardiac muscle fibres of various species

7 January 2021

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Myofibrillar Ca++ activation and heart failure--Ca++ sensitization by the cardiotonic agent APP 201-533.

7 January 2021

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DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties.

7 January 2021

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Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart

7 January 2021

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Effects of pimobendan, a novel inotropic agent, on intracellular calcium and tension in isolated ferret ventricular muscle

7 January 2021

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Pimobendan. A review of its pharmacology and therapeutic potential in congestive heart failure

7 January 2021

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Comparison of the effects of MCI-154, a new cardiotonic agent, and some Ca2+-sensitizing agents on the response of the contractile system to Ca2+ in skinned cardiac muscle.

7 January 2021

1 reference

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The 'calcium sensitising' effects of ORG30029 in saponin- or Triton-skinned rat cardiac muscle

7 January 2021

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Effects of the positive inotropic agent Org 30029 on developed force and aequorin light transients in intact canine ventricular myocardium

7 January 2021

1 reference

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Inotropic and lusitropic effects of MCI-154 (6-[4-(4- pyridyl)aminophenyl]-4,5-dihydro-3(2H)-pyridazinone) on human myocardium

7 January 2021

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Differential effects of the optical isomers of EMD 53998 on contraction and cytoplasmic Ca2+ in isolated ferret cardiac muscle.

7 January 2021

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Characterization of the Cardiotonic Effects of Milrinone, a New and Potent Cardiac Bipyridine, on Isolated Tissues from Several Animal Species

7 January 2021

1 reference

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EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle

7 January 2021

1 reference

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Phosphorylation of the inhibitory subunit of troponin and its effect on the calcium dependence of cardiac myofibril adenosine triphosphatase

7 January 2021

1 reference

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The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers

7 January 2021

1 reference

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A novel thiadiazinone derivative fully reverses acidosis-induced depression of force in cardiac muscle by a calcium-sensitizing effect.

7 January 2021

1 reference

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Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments

7 January 2021

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5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4- dione (BA 41899): Representative of a Novel Class of Purely Calcium-Sensitizing Agents

7 January 2021

1 reference

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The novel inotropic agent CGP 48506 alters force primarily by Ca(2+)-independent mechanisms in porcine skinned trabeculae

7 January 2021

1 reference

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A new cardiotonic drug reduces the energy cost of active tension in cardiac muscle

7 January 2021

1 reference

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The effects of EMD 57033 on rigor tension in porcine skinned cardiac trabecula

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Effects of troponin-I extraction with vanadate and of the calcium sensitizer EMD 53998 on the rate of force generation in skinned cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

The positive inotropic calcium sensitizer EMD 53998 antagonizes phosphate action on cross-bridges in cardiac skinned fibers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Reduction of myocardial cross-bridge turnover rate in presence of EMD 53998, a novel Ca(2+)-sensitizing agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

The effect of EMD 57033, a novel cardiotonic agent, on the relaxation of skinned cardiac and skeletal muscle produced by photolysis of diazo-2, a caged calcium chelator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Photolysis of the novel inotropes EMD 57033 and EMD 57439: evidence that Ca2+ sensitization and phosphodiesterase inhibition depend upon the same enantiomeric site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

The calcium sensitizer EMD 53998 antagonizes phosphate-induced increases in energy cost of isometric tension in cardiac skinned fibres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Effects of calcium and EMD-53998 on oxygen consumption in isolated canine hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Functional and energetic effects of the inotropic agents EMD-57033 and BAPTA on the isolated rat heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Mechanisms of acute ischemic contractile failure of the heart. Role of intracellular calcium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Calcium-sensitizing inotropic agents in the treatment of heart failure: A critical view

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Diastolic Dysfunction in Congestive Heart Failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Significance of Diastolic Dysfunction of the Heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Effects of acidosis and hypoxia on the response of isolated ferret cardiac muscle to inotropic agents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Effects of EMD 57033 on Contraction and Relaxation in Isolated Rabbit Hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Myocardial fibrosis: functional significance and regulatory factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

The contribution of intracellular acidosis to the decline of developed pressure in ferret hearts exposed to cyanide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

EMD 57033 enhances arrhythmias associated with increased wall-stress in the working rat heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

Effects of MCI-154, a calcium sensitizer, on left ventricular systolic and diastolic function in pacing-induced heart failure in the dog

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0008-6363%2897%2900174-0

10.1016/S0008-6363(97)00174-0

7 January 2021

Identifiers

DOI

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6 October 2017

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