(Q41678869)

7 October 2017

1 reference

title

Can drugs be designed? (English)

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7 October 2017

Hubbard RE

1

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7 October 2017

1 December 1997

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Current Opinion in Biotechnology

7 October 2017

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7 October 2017

8

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7 October 2017

696-700

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7 October 2017

6

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Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

7 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-based design of HIV protease inhibitors: 5,6-dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Rational design of potent sialidase-based inhibitors of influenza virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Recognition of DNA by designed ligands at subnanomolar concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-based design of a new bisintercalating anthracycline antibiotic

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Current methods for site-directed structure generation.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Current computational tools for de novo ligand design

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Towards the automatic design of synthetically accessible protein ligands: peptides, amides and peptidomimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Structure-based design of parasitic protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Modeling protein-ligand complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Computational methods to predict binding free energy in ligand-receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

An approach to rapid estimation of relative binding affinities of enzyme inhibitors: application to peptidomimetic inhibitors of the human immunodeficiency virus type 1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Database of three-dimensional structures of HIV proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

The "One-Bead-One-Compound" Combinatorial Library Method

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Designing combinatorial library mixtures using a genetic algorithm

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

1 reference

7 January 2021

Recent solution structures of RNA and its complexes with drugs, peptides and proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980122-X

7 January 2021

10.1016/S0958-1669(97)80122-X

Identifiers

DOI

1 reference

7 October 2017

1 reference

PubMed ID

9425659