(Q41678882)

7 October 2017

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title

How can we use our growing understanding of gene transcription to discover effective new medicines? (English)

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7 October 2017

Latchman DS

1

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7 October 2017

publication date

1 December 1997

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Current Opinion in Biotechnology

7 October 2017

published in

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7 October 2017

volume

8

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7 October 2017

issue

6

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7 October 2017

page(s)

713-717

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Transcription-modulating drugs: mechanism and selectivity

7 October 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Positive selection system to screen for inhibitors of human immunodeficiency virus-1 transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Activation of the human estrogen receptor by estrogenic and antiestrogenic compounds in Saccharomyces cerevisiae: a positive selection system

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Transcription-factor mutations and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Antisense oligonucleotides: towards clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

The nuclear receptor superfamily: the second decade

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

A canonical structure for the ligand-binding domain of nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Nuclear receptor coactivators

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

RIP-140 interacts with multiple nuclear receptors by means of two distinct sites

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Regulation of transcription by MAP kinase cascades

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

A new immunosuppressant: tacrolimus

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

NF-kappa B: ten years after

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Cyclosporin A enhances the calcium-dependent induction of AP-1 complex and c-fos mRNA in a T cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

RNA polymerase II holoenzyme and transcriptional regulation

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Interference with the assembly of a virus-host transcription complex by peptide competition

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Peptide mimetic drugs: a comment on progress and prospects

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https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Sequence-selective intercalation of antitumour bis-naphthalimides into DNA. Evidence for an approach via the major groove.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Substitutions at C2' of daunosamine in the anticancer drug daunorubicin alter its DNA-binding sequence specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Solution structure of the esperamicin A1-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Solution structure of the calicheamicin gamma 1I-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

c-fos protooncogene transcription can be modulated by oligonucleotide-mediated formation of triplex structures in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

Distamycin A complexation with a nucleic acid triple helix

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2897%2980125-5

7 January 2021

10.1016/S0958-1669(97)80125-5

Identifiers

DOI

1 reference

7 October 2017

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