(Q41689734)

7 October 2017

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title

The role of non-P450 enzymes in drug oxidation (English)

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7 October 2017

Beedham C

1

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PubMed ID

9443166

7 October 2017

language of work or name

English

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publication date

1 December 1997

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International Journal of Clinical Pharmacy

7 October 2017

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7 October 2017

19

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7 October 2017

6

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7 October 2017

255-263

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Enantioselective N-oxygenation of verapamil by the hepatic flavin-containing monooxygenase

7 October 2017

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12 December 2020

Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

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12 December 2020

Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles

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12 December 2020

UK-14,304, a potent and selective α2-agonist for the characterisation of α-adrenoceptor subtypes

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12 December 2020

Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver

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12 December 2020

Tolerance and pharmacokinetics of A515U, an acyclovir analogue, in healthy volunteers

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12 December 2020

A chemical and enzymological account of the multiple forms of human liver aldehyde dehydrogenase. Implications for ethnic differences in alcohol metabolism

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12 December 2020

Successors to acyclovir

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12 December 2020

Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substrates

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12 December 2020

Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol

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12 December 2020

Disposition of sumatriptan in laboratory animals and humans

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12 December 2020

Mutational analysis of the human MAOA gene

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12 December 2020

Interactions of some analogues of the anticonvulsant milacemide with monoamine oxidase

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12 December 2020

5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase

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12 December 2020

Formation of N-(5-nitro-2-thiazolyl)-N'-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole

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12 December 2020

Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals

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12 December 2020

Aldehyde oxidase from rabbit liver: specificity toward purines and their analogs

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12 December 2020

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities

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12 December 2020

The interaction of monoamine oxidases with tertiary amines

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12 December 2020

New directions in monoamine oxidase A and B selective inhibitors and substrates

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12 December 2020

Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes

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12 December 2020

6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir

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12 December 2020

Molybdenum hydroxylases: biological distribution and substrate-inhibitor specificity

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12 December 2020

Propranolol metabolism in normal subjects: association with sex steroid hormones

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12 December 2020

The fish-odor syndrome

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12 December 2020

Human liver xanthine oxidase: Nature and extent of individual variation

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12 December 2020

7-Hydroxy-methotrexate and clinical toxicity following high-dose methotrexate therapy

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12 December 2020

Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects

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12 December 2020

Metabolism of nicotine

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12 December 2020

Is the oxidation of milacemide by monoamine oxidase a major factor in its anticonvulsant actions?

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12 December 2020

Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity

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12 December 2020

Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases

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12 December 2020

Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon

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12 December 2020

Influence of genetic variation in alcohol and aldehyde dehydrogenase on serotonin metabolism

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12 December 2020

Milacemide metabolism in rat liver and brain slices by solids NMR.

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12 December 2020

MAOIs, OTC drugs, and hypertensive crisis.

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12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

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12 December 2020

What is it that l-deprenyl (selegiline) might do?

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12 December 2020

Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver

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12 December 2020

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men

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12 December 2020

Xanthine oxidase from human liver: purification and characterization

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12 December 2020

Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy

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12 December 2020

Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers

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12 December 2020

The fish odour syndrome: biochemical, familial, and clinical aspects

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12 December 2020

5-Fluoro-2-pyrimidinone, a liver aldehyde oxidase-activated prodrug of 5-fluorouracil

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12 December 2020

Life-threatening pseudophaeochromocytoma after toloxatone, terbutaline, and phenylephrine

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12 December 2020

Oxidative metabolism of carbazeran in vitro by liver cytosol of baboon and man.

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12 December 2020

Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine

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12 December 2020

In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.

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12 December 2020

Metabolism of amlodipine in the rat and the dog: a species difference

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12 December 2020

Hydroxysteroids are physiological substrates of dehydrogenases for alicyclic alcohols and benzene dihydrodiol in rodent and rabbit liver cytosol

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12 December 2020

Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides

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12 December 2020

Properties and functions of the semicarbazide-sensitive amine oxidases

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12 December 2020

Clinical pharmacokinetics of amlodipine

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12 December 2020

Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials

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12 December 2020

Aldehyde dehydrogenases and their role in carcinogenesis

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12 December 2020

Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]

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12 December 2020

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver

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12 December 2020

Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity

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12 December 2020

Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers

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12 December 2020

Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase

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12 December 2020

The disposition of 6-deoxyacyclovir, a xanthine oxidase-activated prodrug of acyclovir, in the isolated perfused rat liver

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12 December 2020

Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidation

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12 December 2020

Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry

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12 December 2020

Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis

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12 December 2020

Pharmacogenetics of alcohol metabolism and alcoholism

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12 December 2020

Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits

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12 December 2020

Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients

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12 December 2020

Metabolic and pharmacokinetic studies following oral administration of 14C-famciclovir to healthy subjects

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12 December 2020

Metabolism of oxazaphosphorines

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12 December 2020

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro

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12 December 2020

Selective incorporation of iododeoxyuridine into DNA of hepatic metastases versus normal human liver

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12 December 2020

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

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12 December 2020

Oxidation of aldehydes catalyzed by pig liver flavin-containing monooxygenase

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12 December 2020

The role of individual human cytochromes P450 in drug metabolism and clinical response

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12 December 2020

The bioavailability and nonlinear clearance of (-)-carbovir in the rat

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12 December 2020

Flavin-containing monooxygenases: catalytic mechanism and substrate specificities

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12 December 2020

Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism

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12 December 2020

Conversion of 5-iodo-2-pyrimidinone-2'-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design

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12 December 2020

Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections

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12 December 2020

Cytochrome P-450 and FAD-monooxygenase mediated S- and N-oxygenations

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12 December 2020

Role of aldehyde oxidase in biogenic amine metabolism

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12 December 2020

Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys

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12 December 2020

Identifiers

DOI

10.1023/A:1008668913093

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7 October 2017

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PubMed ID

9443166