(Q41702155)

7 October 2017

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title

A risk-benefit assessment of aprotinin in cardiac surgical procedures (English)

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7 October 2017

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W B Dobkowski

1

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7 October 2017

J M Murkin

series ordinal

2

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7 October 2017

publication date

1 January 1998

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7 October 2017

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7 October 2017

volume

18

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7 October 2017

issue

1

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7 October 2017

page(s)

21-41

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High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery.

7 October 2017

cites work

1 reference

12 December 2020

Aprotinin in elective primary bypass surgery. Graft patency and clinical efficacy

1 reference

12 December 2020

The effect of aprotinin (a serine protease inhibitor) on renal function and renin release

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12 December 2020

Hemodynamic consequences of desmopressin administration after cardiopulmonary bypass

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12 December 2020

Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients

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12 December 2020

Systematic use of aprotinin in cardiac surgery: influence on total homologous exposure and hospital cost

1 reference

12 December 2020

Immunological studies on patients who received aprotinin therapy.

1 reference

12 December 2020

The Declining Risk of Post-Transfusion Hepatitis C Virus Infection

1 reference

12 December 2020

A trial of desmopressin (1-desamino-8-D-arginine vasopressin) to reduce blood loss in uncomplicated cardiac surgery.

1 reference

12 December 2020

Coagulopathy after reinfusion of autologous scavenged red blood cells.

1 reference

12 December 2020

Prospective evaluation of posttransfusion hepatitis

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12 December 2020

Aprotinin decreases blood loss in patients undergoing revision or bilateral total hip arthroplasty.

1 reference

12 December 2020

Tranexamic acid (Cyklokapron) is not necessary to reduce blood loss after coronary artery bypass operations

1 reference

12 December 2020

Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin

1 reference

12 December 2020

Repeated dose administration of desmopressin acetate in uncomplicated cardiac surgery: a prospective, blinded, randomized study

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12 December 2020

Low-dose preoperative aspirin therapy, postoperative blood loss, and transfusion requirements

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12 December 2020

A six year study of incompatible blood transfusions

1 reference

12 December 2020

Safety and efficacy of aprotinin under conditions of deep hypothermia and circulatory arrest

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12 December 2020

Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery.

1 reference

12 December 2020

Aprotinin (trasylol) is a competitive inhibitor of activated protein C

1 reference

12 December 2020

Effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation

1 reference

12 December 2020

Aprotinin in therapeutic doses inhibits chromogenic peptide substrate assays for protein C

1 reference

12 December 2020

The role of desmopressin acetate in patients undergoing coronary artery bypass surgery. A controlled clinical trial with thromboelastographic risk stratification

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12 December 2020

The effect of desmopressin acetate (DDAVP) on postoperative blood loss after cardiac operations in children

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12 December 2020

Aprotinin in peripheral vascular surgery

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12 December 2020

Tranexamic acid and arterial thrombosis

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12 December 2020

Clinical application of inhibitors of fibrinolysis

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12 December 2020

Does desmopressin acetate prophylaxis reduce blood loss after valvular heart operations? A randomized, double-blind study

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12 December 2020

Postoperative use of aprotinin in cardiac operations: an alternative to its prophylactic use

1 reference

12 December 2020

Reduction of thrombosis in canine coronary bypass vein grafts with dipyridamole and aspirin

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12 December 2020

Prophylactic treatment of postperfusion bleeding using EACA.

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12 December 2020

Continuous small-dose aprotinin controls fibrinolysis during orthotopic liver transplantation.

1 reference

12 December 2020

Prophylactic tranexamic acid decreases bleeding after cardiac operations.

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12 December 2020

Epsilon Aminocaproic Acid — A Dangerous Weapon

1 reference

12 December 2020

Effects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation

1 reference

12 December 2020

Influence of high-dose aprotinin on anticoagulation, heparin requirement, and celite- and kaolin-activated clotting time in heparin-pretreated patients undergoing open-heart surgery. A double-blind, placebo-controlled study

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12 December 2020

Relationship of transfusion and infection in a burn population.

1 reference

12 December 2020

Aprotinin for coronary artery bypass grafting: Effect on postoperative renal function

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12 December 2020

Effect of aprotinin on need for blood transfusion after repeat open-heart surgery

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12 December 2020

Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs.

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12 December 2020

Blood Conservation Techniques and Platelet Function in Cardiac Surgery

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12 December 2020

Reversible translocation of glycoprotein Ib in plasmin-treated platelets: consequences for platelet function

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12 December 2020

Fibrinolytic mechanisms and the development of thrombolytic therapy

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12 December 2020

Aprotinin reduces intraoperative and postoperative blood loss in membrane oxygenator cardiopulmonary bypass

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12 December 2020

Inhibition of platelet function by heparin. An etiologic factor in postbypass hemorrhage

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12 December 2020

Deceptively low morbidity from failure to practice safe blood transfusion: an analysis of serious blood transfusion errors

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12 December 2020

The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study

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12 December 2020

Does desmopressin acetate reduce blood loss after surgery in patients on cardiopulmonary bypass?

1 reference

12 December 2020

Influence of High-dose Aprotinin Treatment on Blood Loss and Coagulation Patterns in Patients Undergoing Myocardial Revascularization

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12 December 2020

Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders

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12 December 2020

Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation

1 reference

12 December 2020

Therapeutic trial of cerebral vasospasm with the serine protease inhibitor, FUT-175, administered in the acute stage after subarachnoid hemorrhage

1 reference

12 December 2020

Predonated autologous blood use in elective cardiac surgery

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12 December 2020

Aprotinin prevents cardiopulmonary bypass-induced platelet dysfunction. A scanning electron microscope study.

1 reference

12 December 2020

Cerebral emboli and cognitive outcome after cardiac surgery

1 reference

12 December 2020

Autotransfusion after open heart surgery: characteristics of shed mediastinal blood and its influence on the plasma proteases in circulating blood.

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12 December 2020

Effect of low-dose aprotinin on coagulation and fibrinolysis in cardiopulmonary bypass

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12 December 2020

Arteriopathic complications during treatment of subarachnoid hemorrhage with epsilon-aminocaproic acid

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12 December 2020

Blood transfusion and postoperative infection in orthopedic patients

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12 December 2020

EFFECTS OF EPSILON AMINOCAPROIC ACID ON COAGULATION AND FIBRINOLYTIC MECHANISMS

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12 December 2020

Brain swelling in first hour after coronary artery bypass surgery.

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12 December 2020

PROBLEMS IN HEMOSTASIS WITH EXTRACORPOREAL APPARATUS

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12 December 2020

A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. II. Neurologic and cognitive outcomes.

1 reference

12 December 2020

Effect of celite and kaolin on activated clotting time in the presence of aprotinin: activated clotting time is reduced by binding of aprotinin to kaolin

1 reference

12 December 2020

Predeposited autologous blood for elective surgery. A national multicenter study

1 reference

12 December 2020

Aprotinin: safe and effective only with the full-dose regimen

1 reference

12 December 2020

Pharmacokinetics of aprotinin in preoperative cardiac surgical patients

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12 December 2020

Clinical use of synthetic antifibrinolytic agents during liver transplantation

1 reference

12 December 2020

Effect of aprotinin (Trasylol) on aorta-coronary bypass graft patency

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12 December 2020

Acute platelet-rich plasmapheresis for cardiac surgery

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12 December 2020

A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting

1 reference

12 December 2020

Intraoperative blood salvage: a review

1 reference

12 December 2020

Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood

1 reference

12 December 2020

Aprotinin in primary valve replacement and reconstruction: a multicenter, double-blind, placebo-controlled trial.

1 reference

12 December 2020

Desmopressin acetate in uncomplicated coronary artery bypass surgery: a prospective randomized clinical trial

1 reference

12 December 2020

Desmopressin acetate is a mild vasodilator that does not reduce blood loss in uncomplicated cardiac surgical procedures.

1 reference

12 December 2020

In vitro effects of aprotinin on activated clotting time measured with different activators.

1 reference

12 December 2020

Preventive effect of synthetic serine protease inhibitor, FUT-175, on cerebral vasospasm in rabbits

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12 December 2020

Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest

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12 December 2020

Hemostasis in Massively Transfused Trauma Patients

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12 December 2020

Guidelines for monitoring heparin by the activated clotting time when aprotinin is used during cardiopulmonary bypass

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12 December 2020

Letter: Tranexamic acid and intracranial thrombosis

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12 December 2020

Risk of infection after penetrating abdominal trauma

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12 December 2020

The intra-operative use of trasylol (aprotinin) in liver transplantation

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12 December 2020

PATHOLOGICAL FIBRINOLYSIS.

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12 December 2020

Reduction of heparin binding to and inhibition of platelets by aprotinin

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12 December 2020

Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations.

1 reference

12 December 2020

Transfusion reaction. An immunologic hazard of blood transfusion

1 reference

12 December 2020

Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty.

1 reference

12 December 2020

Aprotinin protects platelets against the initial effect of cardiopulmonary bypass

1 reference

12 December 2020

Aprotinin-ACD-blood: I. Experimental studies on the effect of aprotinin on the plasmatic and thrombocytic coagulation (author's transl)

1 reference

12 December 2020

The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors

1 reference

12 December 2020

Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass

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12 December 2020

1 reference

12 December 2020

Postoperative hemostasis and fibrinolysis in patients undergoing cardiopulmonary bypass with or without aprotinin therapy

1 reference

12 December 2020

Aprotinin reduces the need for blood products during liver transplantation.

1 reference

12 December 2020

Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol).

1 reference

12 December 2020

Is there a phase of hypercoagulability when aprotinin is usedin cardiac surgery?

1 reference

12 December 2020

Relationship of postoperative septic complications and blood transfusions in patients with Crohn's disease

1 reference

12 December 2020

The effect of desmopressin acetate on postoperative hemorrhage in patients receiving aspirin therapy before coronary artery bypass operations

1 reference

12 December 2020

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone

1 reference

12 December 2020

Prevention of postbypass bleeding with tranexamic acid and epsilon-aminocaproic acid.

1 reference

12 December 2020

Massive pulmonary thromboembolism after tranexamic acid antifibrinolytic therapy

1 reference

12 December 2020

Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients

1 reference

12 December 2020

Platelet protection by low-dose aprotinin in cardiopulmonary bypass: electron microscopic study

1 reference

12 December 2020

Heparin resistance after aprotinin.

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12 December 2020

Cardiopulmonary bypass. Associated hemostatic abnormalities

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12 December 2020

Thrombotic state after a hemorrhagic diathesis, a possible complication of therapy with epsilon-aminocapproic acid

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12 December 2020

Effects of progressive blood loss on coagulation as measured by thrombelastography.

1 reference

12 December 2020

Specificity of lymphocytotoxic antibodies formed after cardiac transplantation and correlation with rejection episodes

1 reference

12 December 2020

Cardiopulmonary bypass and the inflammatory response: a role for serine protease inhibitors?

1 reference

12 December 2020

The role of epsilon-aminocaproic acid in reducing bleeding after cardiac operation: a double-blind randomized study

1 reference

12 December 2020

Aprotinin versus desmopressin for patients undergoing operations with cardiopulmonary bypass. A double-blind placebo-controlled study

1 reference

12 December 2020

Platelet-rich plasma reduces postoperative blood loss after cardiopulmonary bypass.

1 reference

12 December 2020

Mechanisms of thrombin generation during surgery and cardiopulmonary bypass

1 reference

12 December 2020

High-dose aprotinin: hemostatic effects in open heart operations.

1 reference

12 December 2020

Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial

1 reference

12 December 2020

Cerebral Thrombosis Associated with Amicar Therapy

1 reference

12 December 2020

High-dose aprotinin in cardiac surgery: three years' experience in 1,784 patients

1 reference

12 December 2020

Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass

1 reference

12 December 2020

Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens

1 reference

12 December 2020

Low-dose and high-dose aprotinin improve hemostasis in coronary operations

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12 December 2020

Aprotinin does not compromise arterial graft patency in coronary bypass operations

1 reference

12 December 2020

Aprotinin use in patients with dialysis-dependent renal failure undergoing cardiac operations

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12 December 2020

Profound normovolemic hemodilution: hemostatic effects in patients and in a porcine model

1 reference

12 December 2020

Aprotinin for coronary bypass operations: efficacy, safety, and influence on early saphenous vein graft patency. A multicenter, randomized, double-blind, placebo-controlled study

1 reference

12 December 2020

High-dose aprotinin therapy: a review of the first five years' experience

1 reference

12 December 2020

Aprotinin is a competitive inhibitor of the factor VIIa-tissue factor complex

1 reference

12 December 2020

Aprotinin therapy for reoperative myocardial revascularization: A placebo-controlled study

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12 December 2020

Complement and the damaging effects of cardiopulmonary bypass

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12 December 2020

Anticoagulation policy during use of aprotinin in cardiopulmonary bypass

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12 December 2020

Aprotinin and bleeding in profoundly hypothermic perfusion

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12 December 2020

Increased anticoagulation during cardiopulmonary bypass by aprotinin.

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12 December 2020

Anaphylactic reaction to aprotinin

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12 December 2020

The haemostatic response to surgery and trauma

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12 December 2020

Plasmin effect on platelet glycoprotein Ib-von Willebrand factor interactions

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12 December 2020

Anaphylactic reaction to aprotinin during cardiac surgery.

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12 December 2020

Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom

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12 December 2020

Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding.

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12 December 2020

The role of bradykinin in mediating ischemic brain edema in rats

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12 December 2020

Effects of aprotinin on prostaglandin metabolism and platelet function in open heart surgery

1 reference

12 December 2020

Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit

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12 December 2020

Desmopressin acetate following cardiopulmonary bypass: evaluation of coagulation parameters

1 reference

12 December 2020

Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass

1 reference

12 December 2020

10.2165/00002018-199818010-00003

Identifiers

DOI

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Dimensions Publication ID

7 October 2017

1005671092

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