(Q41714552)

English

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

scientific article published on December 1999

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10637514%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1 (English)

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Europe PubMed Central

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3 November 2019

2

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3 November 2019

author name string

Calvo KR

1

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3 November 2019

McGrath S

3

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3 November 2019

Kamps MP

4

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3 November 2019

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1 December 1999

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3 November 2019

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3 November 2019

18

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3 November 2019

56

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3 November 2019

8033-8043

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3 November 2019

Control of the nuclear localization of Extradenticle by competing nuclear import and export signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1 reference

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21 January 2018

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Prep1, a novel functional partner of Pbx proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Characterization of UEF-4, a DNA-binding protein required for transcriptional synergism between two AP-1 sites in the human urokinase enhancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Characterization of the cooperative function of inhibitory sequences in Ets-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Roles of phosphorylation sites in regulating activity of the transcription factor Pho4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in viv

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Localization of E2A mRNA expression in developing and adult rat tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Localization of Pbx1 transcripts in developing rat embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Studies on the mechanism of glucocorticoid-mediated repression from a negative glucocorticoid response element from the bovine prolactin gene

1 reference

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21 January 2018

Glucocorticoids repress transcription from a negative glucocorticoid response element recognized by two homeodomain-containing proteins, Pbx and Oct-1.

1 reference

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21 January 2018

extradenticle raises the DNA binding specificity of homeotic selector gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

21 January 2018

Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Functional and cooperative interactions between the homeodomain PDX1, Pbx, and Prep1 factors on the somatostatin promoter

1 reference

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7 January 2021

based on heuristic

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The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

1 reference

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7 January 2021

based on heuristic

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Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

7 January 2021

based on heuristic

inferred from DOI database lookup

Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel modulator domain of Ets transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203377

7 January 2021

based on heuristic

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New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia

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7 January 2021

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Identifiers

10.1038/SJ.ONC.1203377

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10637514%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10637514%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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