(Q41718191)

English

AIDS pathogenesis: the role of accessory gene mutations, leading to formation of long-lived persistently infected cells and/or apoptosis-inducing HIV-1 particles.

scientific article published on December 1997

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scholarly article

1 reference

Europe PubMed Central

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9 November 2019

1 reference

Europe PubMed Central

AIDS pathogenesis: the role of accessory gene mutations, leading to formation of long-lived persistently infected cells and/or apoptosis-inducing HIV-1 particles (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9495530%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Masanori Kameoka

2

1 reference

Europe PubMed Central

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9 November 2019

author name string

K Ikuta

1

1 reference

Europe PubMed Central

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9 November 2019

R B Luftig

3

1 reference

Europe PubMed Central

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9 November 2019

publication date

1 December 1997

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9495530%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9495530%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

52

1 reference

Europe PubMed Central

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9 November 2019

2

1 reference

Europe PubMed Central

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9 November 2019

145-156

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9495530%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

The relevance of apoptosis to AIDS pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Production of doughnut-shaped, protease-defective particles from a human T cell clone carrying a provirus with specific mutations in the env, pol, vpr, and nef genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV's other immune-system targets: macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of HIV-1 latency

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Follicular dendritic cells (FDC) in retroviral infection: host/pathogen perspectives

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical Evaluation of Branched DNA Signal Amplification for Quantifying HIV Type 1 in Human Plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Multifactorial nature of human immunodeficiency virus disease: implications for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The sor gene of HIV-1 is required for efficient virus transmission in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Growth dominance of a revertant virus generated during in vitro serial passage of nef frameshift mutant of HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular transcription factors involved in the regulation of HIV-1 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Programmed cell death in AIDS-related HIV and SIV infections.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type 1 clones derived from a single individual

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective human immunodeficiency virus (HIV) particles produced by cloned cells of HTLV-I-carrying MT-4 cells persistently infected with HIV.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Exposure of resting peripheral blood T cells to HIV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cells surviving infection by human immunodeficiency virus type 1: vif or vpu mutants produce non-infectious or markedly less cytopathic viruses

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Persistently human immunodeficiency virus type 1-infected T cell clone expressing only doubly spliced mRNA exhibits reduced cell surface CD4 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Superinfection of a defective human immunodeficiency virus type 1 provirus-carrying T cell clone with vif or vpu mutants gives cytopathic virus particles by homologous recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Bone-marrow-derived dendritic cells and the pathogenesis of AIDS

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional analysis of HIV-1 Vpr: identification of determinants essential for subcellular localization.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral latency in HIV disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Programmed death of T cells in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonsense mutations in the vpr gene of HIV-1 during in vitro virus passage and in HIV-1 carrier-derived peripheral blood mononuclear cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Serial passage of human immunodeficiency virus type 1 generates misalignment deletions in non-essential accessory genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1vif, vpr, andvpu mutants can produce persistently infected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Persistent infection of MT-4 cells by human immunodeficiency virus type 1 becomes increasingly likely with in vitro serial passage of wild-type but not nef mutant virus

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutational analysis of the human immunodeficiency virus vpr open reading frame.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Decay characteristics of HIV-1-infected compartments during combination therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular latency of human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Productive HIV-1 infection of macrophages restricted to the cell fraction with proliferative capacity.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The HIV 'A' (sor) gene product is essential for virus infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel gene of HIV-1, vpu, and its 16-kilodalton product

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional role of human immunodeficiency virus type 1 vpu.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene Defects Clustered at the C-Terminus of the vpr Gene of HIV-1 in Long-Term Nonprogressing Mother and Child Pair:In VivoEvolution of vpr Quasispecies in Blood and Plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral dynamics in human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of HIV-1 latency reactivation by dehydroepiandrosterone (DHEA) and an analog of DHEA.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Production of infectious particles from defective human immunodeficiency virus type 1 (HIV-1)-producing cell clones by superinfection with infectious HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2897%2900125-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0168-1702(97)00125-1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9495530%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9495530%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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