(Q41721470)

8 October 2017

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title

RNA as a drug target: chemical, modelling, and evolutionary tools (English)

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8 October 2017

Hermann T

1

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8 October 2017

Westhof E

series ordinal

2

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8 October 2017

publication date

1 February 1998

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Current Opinion in Biotechnology

8 October 2017

published in

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8 October 2017

volume

9

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8 October 2017

issue

1

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8 October 2017

page(s)

66-73

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Combinatorial thinking in chemistry and biology

8 October 2017

cites work

1 reference

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7 January 2021

A convergent solid-phase synthesis of actinomycin analogues--towards implementation of double-combinatorial chemistry.

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7 January 2021

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

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7 January 2021

Strategy for RNA recognition by yeast histidyl-tRNA synthetase

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7 January 2021

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7 January 2021

A Structural Basis for RNAminus signLigand Interactions

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7 January 2021

In vitro selection of aptamers: the dearth of pure reason

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7 January 2021

Aptamer structures from A to zeta

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7 January 2021

Structure, recognition and adaptive binding in RNA aptamer complexes

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7 January 2021

Interaction of antibiotics with functional sites in 16S ribosomal RNA

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7 January 2021

RNA sequence determinants for aminoglycoside binding to an A-site rRNA model oligonucleotide

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7 January 2021

An antibiotic-binding motif of an RNA fragment derived from the A-site-related region of Escherichia coli 16S rRNA.

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7 January 2021

Specificity of aminoglycoside binding to RNA constructs derived from the 16S rRNA decoding region and the HIV-RRE activator region

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7 January 2021

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

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7 January 2021

Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA.

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7 January 2021

Antibiotic inhibition of group I ribozyme function

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7 January 2021

Inhibition of the self-cleavage reaction of the human hepatitis delta virus ribozyme by antibiotics

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7 January 2021

Inhibition of self-splicing group I intron RNA: high-throughput screening assays

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7 January 2021

Bidirectional effectors of a group I intron ribozyme

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7 January 2021

Non-competitive inhibition of group I intron RNA self-splicing by aminoglycoside antibiotics

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7 January 2021

Peptide antibiotics of the tuberactinomycin family as inhibitors of group I intron RNA splicing

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7 January 2021

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

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7 January 2021

Discovery of selective, small-molecule inhibitors of RNA complexes--II. Self-splicing group I intron ribozyme

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7 January 2021

Protein synthesis inhibitors and catalytic RNA. Effect of puromycin on tRNA precursor processing by the RNA component of Escherichia coli RNase P.

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7 January 2021

Three-dimensional structure of a hammerhead ribozyme

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7 January 2021

The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage

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7 January 2021

Neomycin inhibition of the hammerhead ribozyme involves ionic interactions

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7 January 2021

Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA

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7 January 2021

Specific binding of aminoglycoside antibiotics to RNA.

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7 January 2021

In vitro selection of RNA lectins: using combinatorial chemistry to interpret ribozyme evolution

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7 January 2021

A novel RNA motif for neomycin recognition

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7 January 2021

In vitro selection analysis of neomycin binding RNAs with a mutagenized pool of variants of the 16S rRNA decoding region

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7 January 2021

In vitro selection of a viomycin-binding RNA pseudoknot

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7 January 2021

RNA molecules that specifically and stoichiometrically bind aminoglycoside antibiotics with high affinities

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex

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7 January 2021

The search for structure-specific nucleic acid-interactive drugs: effects of compound structure on RNA versus DNA interaction strength

1 reference

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7 January 2021

RNA-diethylstilbestrol interaction studied by Fourier transform infrared difference spectroscopy.

1 reference

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7 January 2021

A molecular mechanics investigation of RNA complexes. I. Ethidium intercalation in an HIV-1 TAR RNA sequence with an unpaired adenosine

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

The binding mode of drugs to the TAR RNA of HIV-1 studied by electric linear dichroism

1 reference

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7 January 2021

Enediyne-mediated cleavage of RNA

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7 January 2021

Effect of ribonucleotide substitution on nucleic acid bulge recognition by neocarzinostatin

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7 January 2021

Selective cleavages of tRNAPhe with secondary and tertiary structures by enediyne antitumor antibiotics

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7 January 2021

Design and analysis of molecular motifs for specific recognition of RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Recognition of G-U mismatches by tris(4,7-diphenyl-1,10-phenanthroline)rhodium(III)

1 reference

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7 January 2021

Isoalloxazine derivatives promote photocleavage of natural RNAs at G.U base pairs embedded within helices

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Sequence-specific hydrolysis of yeast tRNA(Phe) mediated by metal-free bleomycin

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

On the chemistry of RNA degradation by Fe.bleomycin

1 reference

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7 January 2021

Using guanidinium groups for the recognition of RNA and as catalysts for the hydrolysis of RNA.

1 reference

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7 January 2021

RNA recognition by the human immunodeficiency virus Tat and Rev proteins

1 reference

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7 January 2021

Arginine-binding RNAs resembling TAR identified by in vitro selection

1 reference

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7 January 2021

Selection of RNA-binding peptides in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Structural change in Rev responsive element RNA of HIV-1 on binding Rev peptide

1 reference

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7 January 2021

Deep penetration of an alpha-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Solution structure of the HIV-2 TAR-argininamide complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Inhibition of HIV-1 Rev-RRE interaction by diphenylfuran derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Targeting the Tat-binding site of bovine immunodeficiency virus TAR RNA with a shape-selective rhodium complex

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

A non-canonical base pair within the human immunodeficiency virus rev-responsive element is involved in both rev and small molecule recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Modulation of the Rev-RRE interaction by aromatic heterocyclic compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Major groove accessibility of RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

RNA structure comes of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Structure-based discovery of ligands targeted to the RNA double helix.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Evidence for a hydroxide ion bridging two magnesium ions at the active site of the hammerhead ribozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Molecular dynamics investigations of hammerhead ribozyme RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

Calculations of nucleic acid conformations

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2898%2980086-4

7 January 2021

10.1016/S0958-1669(98)80086-4

Identifiers

DOI

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8 October 2017

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