(Q41763474)

English

The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7

scientific article published on March 2009

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scholarly article

1 reference

Europe PubMed Central

9 October 2017

The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7 (English)

1 reference

Europe PubMed Central

9 October 2017

author name string

Simone L Sandiford

1

1 reference

Europe PubMed Central

9 October 2017

Vladlen Z Slepak

2

1 reference

Europe PubMed Central

9 October 2017

language of work or name

0 references

publication date

1 March 2009

1 reference

Europe PubMed Central

9 October 2017

number of pages

8

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based on heuristic

inferred from page(s)

1 reference

Europe PubMed Central

9 October 2017

48

1 reference

Europe PubMed Central

9 October 2017

10

1 reference

Europe PubMed Central

9 October 2017

2282-2289

1 reference

Europe PubMed Central

9 October 2017

R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Crystal structure of the multifunctional Gβ5–RGS9 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Muscarinic acetylcholine receptor subtype expression in avian vestibular hair cells, nerve terminals and ganglion cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

DEP-domain-mediated regulation of GPCR signaling responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Mammalian RGS proteins: multifunctional regulators of cellular signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

RGS protein and G protein interactions: a little help from their friends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

A novel kind of G protein heterodimer: the G beta5-RGS complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Copurification of brain G-protein beta5 with RGS6 and RGS7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Whither goest the RGS proteins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Mammalian RGS proteins: barbarians at the gate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Pleckstrin's repeat performance: a novel domain in G-protein signaling?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

6 June 2018

Functional role of the third cytoplasmic loop in muscarinic receptor dimerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

16 June 2018

Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

18 August 2018

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

18 August 2018

Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

18 August 2018

Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766429

18 August 2018

Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the Gbeta5-RGS7 protein complex in the retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heptahelical terpsichory. Who calls the tune?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/19182865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI801989C

1 reference

Europe PubMed Central

9 October 2017

1 reference

Europe PubMed Central

9 October 2017

1 reference

Europe PubMed Central

9 October 2017

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