(Q41771962)

9 October 2017

An Hsp90 modulator that exhibits a unique mechanistic profile (English)

1 reference

9 October 2017

Deborah M Ramsey

1

1 reference

9 October 2017

Jeanette R McConnell

2

1 reference

9 October 2017

Leslie D Alexander

3

1 reference

9 October 2017

Kaishin W Tanaka

4

1 reference

9 October 2017

Chester M Vera

5

1 reference

9 October 2017

Shelli R McAlpine

6

1 reference

9 October 2017

language of work or name

English

0 references

publication date

11 March 2012

1 reference

Bioorganic & Medicinal Chemistry Letters

9 October 2017

1 reference

9 October 2017

22

1 reference

9 October 2017

9

1 reference

9 October 2017

3287-3290

1 reference

Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins

9 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Targeting the dynamic HSP90 complex in cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Heat shock protein 90: inhibitors in clinical trials.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Comprehensive study of sansalvamide A derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Poly(ADP-ribose) makes a date with death

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

The middle domain of Hsp90 acts as a discriminator between different types of client proteins

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Structure and in vivo function of Hsp90.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Synthesis of second-generation sansalvamide A derivatives: novel templates as potential antitumor agents.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

The C-terminal half of Hsp90 is responsible for its cytoplasmic localization

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Hsp90 Recognizes a Common Surface on Client Kinases

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337333

Evidence that the 90-kilodalton heat shock protein is associated with tubulin-containing complexes in L cell cytosol and in intact PtK cells

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22480433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Requirement of heat shock protein 90 in mesangial cell mitogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22480433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22480433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2012.03.012

1 reference

9 October 2017

1 reference

9 October 2017

PubMed publication ID

22480433

1 reference