(Q41778085)

English

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261

scientific article published on June 2006

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261 (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

author name string

Zachary Newby

1

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Tom T Lee

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Richard J Morse

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Yaoquan Liu

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Lu Liu

5

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Prasanna Venkatraman

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Daniel V Santi

7

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Janet S Finer-Moore

8

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Robert M Stroud

9

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Europe PubMed Central

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9 October 2017

language of work or name

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publication date

1 June 2006

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Europe PubMed Central

PMC publication ID

9 October 2017

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

45

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Europe PubMed Central

PMC publication ID

9 October 2017

24

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

7415-7428

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".

1 reference

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6 June 2018

Normal mode analysis of macromolecular motions in a database framework: developing mode concentration as a useful classifying statistic

1 reference

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6 June 2018

Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance"

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Efficient anisotropic refinement of macromolecular structures using FFT

1 reference

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6 June 2018

Rapid automated molecular replacement by evolutionary search

1 reference

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6 June 2018

Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer

1 reference

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6 June 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

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6 June 2018

The additivity of substrate fragments in enzyme-ligand binding

1 reference

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6 June 2018

Thymidylate synthase: structure, inhibition, and strained conformations during catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase

1 reference

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6 June 2018

The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.

1 reference

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6 June 2018

Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

A perspective on biological catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Significance of structural changes in proteins: expected errors in refined protein structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Hydrogen bonding and biological specificity analysed by protein engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Crystallographic refinement by simulated annealing. Application to a 2.8 A resolution structure of aspartate aminotransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Saturation site-directed mutagenesis of thymidylate synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Site-directed mutagenesis of arginine 179 of thymidylate synthase. A nonessential substrate-binding residue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Chemical synthesis of the thymidylate synthase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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6 June 2018

Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556892

6 June 2018

The folding of an enzyme. II. Substructure of barnase and the contribution of different interactions to protein stability

1 reference

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6 June 2018

Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity

1 reference

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6 June 2018

Purification methods for recombinant Lactobacillus casei thymidylate synthase and mutants: a general, automated procedure.

1 reference

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6 June 2018

Vibrationally enhanced hydrogen tunneling in the Escherichia coli thymidylate synthase catalyzed reaction

1 reference

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Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

1 reference

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Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.

1 reference

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Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase

1 reference

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Complete replacement set of amino acids at the C-terminus of thymidylate synthase: quantitative structure-activity relationship of mutants of an enzyme

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/16768437

12 December 2020

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Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16768437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Factors Contributing to the Hydrophobic Effect: The Partly Exposed Hydrophobic Minicore in Chymotrypsin Inhibitor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16768437

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Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/16768437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI060152S

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

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https://api.fatcat.wiki/v0/release/z7eaj4sg45b3de7i2vz65zuq64

24 November 2022

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PMC publication ID

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Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

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Europe PubMed Central

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9 October 2017

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