(Q41790826)

10 October 2017

Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis (English)

1 reference

10 October 2017

Paul S Marinec

1

1 reference

10 October 2017

Christopher G Evans

2

1 reference

10 October 2017

Garrett S Gibbons

3

1 reference

10 October 2017

Malloree A Tarnowski

4

1 reference

10 October 2017

Daniel L Overbeek

5

1 reference

10 October 2017

Jason E Gestwicki

6

1 reference

10 October 2017

language of work or name

English

0 references

publication date

18 July 2009

1 reference

Bioorganic & Medicinal Chemistry

10 October 2017

1 reference

10 October 2017

17

1 reference

10 October 2017

16

1 reference

10 October 2017

5763-5768

1 reference

FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo

10 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Chemical control over protein-protein interactions: beyond inhibitors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

The remarkable metal-catalysed olefin metathesis reaction

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Efficient removal of ruthenium byproducts from olefin metathesis products by simple aqueous extraction

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A small-molecule switch for Golgi sulfotransferases

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Chemical complementation: a reaction-independent genetic assay for enzyme catalysis.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Regulation of endogenous gene expression with a small-molecule dimerizer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A synthetic library of cell-permeable molecules

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

FK506, an immunosuppressant targeting calcineurin function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A versatile synthetic dimerizer for the regulation of protein-protein interactions

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Controlling signal transduction with synthetic ligands

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

The anchor-away technique: rapid, conditional establishment of yeast mutant phenotypes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A small molecule-directed approach to control protein localization and function

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Bifunctional molecules evade cytochrome P(450) metabolism by forming protective complexes with FK506-binding protein

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Optimized synthesis of hydrogen-bond surrogate helices: surprising effects of microwave heating on the activity of Grubbs catalysts

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A convenient method to remove ruthenium byproducts from olefin metathesis reactions using polymer-bound triphenylphosphine oxide (TPPO).

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A general model for selectivity in olefin cross metathesis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

A bifunctional molecule that displays context-dependent cellular activity

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

An inducible system for the study of FGF signalling in early amphibian development.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758530

Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy

18 August 2018

1 reference

12 December 2020

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

12 December 2020

A convenient method for the efficient removal of ruthenium byproducts generated during olefin metathesis reactions

1 reference

12 December 2020

In Vivo Protein-Protein Interaction Assays: Beyond Proteins We would like to thank Tony Siu, Dr. Charles Cho, and the members of our lab for their helpful comments as we were preparing this manuscript

1 reference

12 December 2020

Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

1 reference

12 December 2020

Dissecting the Functions of Proteins and Pathways using Chemically Induced Dimerization

1 reference

12 December 2020

10.1016/J.BMC.2009.07.030

Identifiers

DOI

1 reference

10 October 2017

1 reference

10 October 2017

PubMed publication ID

19643614

1 reference