(Q41809171)

English

cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway.

scientific article published on 12 April 2011

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21487005%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21487005%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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28 January 2020

6

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28 January 2020

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28 January 2020

author name string

Bing Shen

1

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28 January 2020

Xin Ma

3

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28 January 2020

Ching-On Wong

4

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28 January 2020

Juan Du

5

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28 January 2020

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publication date

12 April 2011

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28 January 2020

Journal of Biological Chemistry

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28 January 2020

286

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28 January 2020

22

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28 January 2020

19439-19445

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28 January 2020

Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane

1 reference

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Transient receptor potential channelopathies

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Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6.

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6 June 2018

Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation.

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6 June 2018

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Epac proteins: multi-purpose cAMP targets

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6 June 2018

Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells

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Glucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C.

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6 June 2018

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

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6 June 2018

Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells

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Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).

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6 June 2018

Regulation of TRPC6 channel activity by tyrosine phosphorylation

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6 June 2018

Signalling from adenosine receptors to mitogen-activated protein kinases

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Hyperfiltration and glomerulosclerosis

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Cyclic nucleotide analogs as biochemical tools and prospective drugs

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Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

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Expression patterns of sarco/endoplasmic reticulum Ca(2+)-ATPase and inositol 1,4,5-trisphosphate receptor isoforms in vascular endothelial cells

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6 June 2018

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

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Calcium oscillations in pituitary gonadotrophs: comparison of experiment and theory

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A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration

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6 June 2018

Critical role of TRPC6 channels in the formation of excitatory synapses.

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18 August 2018

Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells.

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Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels

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based on heuristic

inferred from PubMed ID database lookup

Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes

1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.210294

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21487005%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21487005%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21487005%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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