(Q418137)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00492

Hypoxanthine phosphoribosyl transferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00492

Phosphoribosyltransferase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Hypoxanthine-guanine phosphoribosyltransferase 1BZY.png
1,000 × 931; 520 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

protein homodimerization activity

1 reference

8 April 2019

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

glycosyltransferase activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

hypoxanthine phosphoribosyltransferase activity

8 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

4 references

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

An empirical framework for binary interactome mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

IPI

magnesium ion binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

hypoxanthine phosphoribosyltransferase activity

9 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 January 2018

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

hypoxanthine phosphoribosyltransferase activity

EXP

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

extracellular exosome

2 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

purine nucleotide biosynthetic process

HDA

biological process

1 reference

8 April 2019

Purine metabolism in female heterozygotes for hypoxanthine-guanine phosphoribosyltransferase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

purine ribonucleoside salvage

4 references

26 September 2017

Purine metabolism in female heterozygotes for hypoxanthine-guanine phosphoribosyltransferase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

GMP catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

dendrite morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

response to amphetamine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

purine-containing compound salvage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

nucleoside metabolic process

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

dopamine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

central nervous system neuron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

lymphocyte proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

cerebral cortex neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

IMP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

protein homotetramerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

8 April 2019

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

adenine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00492&geneProductId=UniProtKB:P00492

T cell mediated cytotoxicity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

purine ribonucleoside salvage

5 references

8 April 2019

Purine metabolism in female heterozygotes for hypoxanthine-guanine phosphoribosyltransferase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

hypoxanthine metabolic process

IBA

3 references

8 April 2019

Purine metabolism in female heterozygotes for hypoxanthine-guanine phosphoribosyltransferase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00492

http://purl.uniprot.org/uniprot/P00492

IBA

Gene Atlas image

PBB GE HPRT1 202854 at fs.png
732 × 530; 12 KB

0 references

exact match

1 reference

Phosphoribosyltransferase domain

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P00492

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016