(Q41814389)

English

Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling

scientific article published on 28 September 2012

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scholarly article

1 reference

Europe PubMed Central

12 October 2017

Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling (English)

1 reference

Europe PubMed Central

12 October 2017

Drosophila melanogaster

0 references

1

1 reference

Europe PubMed Central

12 October 2017

author name string

Daisy Madder

2

1 reference

Europe PubMed Central

12 October 2017

Varun Chaudhary

3

1 reference

Europe PubMed Central

12 October 2017

Peter J Artymiuk

4

1 reference

Europe PubMed Central

12 October 2017

language of work or name

0 references

publication date

28 September 2012

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

192

1 reference

Europe PubMed Central

12 October 2017

4

1 reference

Europe PubMed Central

12 October 2017

1295-1313

1 reference

Europe PubMed Central

12 October 2017

Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Yellow submarine of the Wnt/Frizzled signaling: submerging from the G protein harbor to the targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

I-TASSER: a unified platform for automated protein structure and function prediction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Towards an integrated view of Wnt signaling in development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Proximal events in Wnt signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Differential stability of flamingo protein complexes underlies the establishment of planar polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Template-based modeling and free modeling by I-TASSER in CASP7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Differential activities of the core planar polarity proteins during Drosophila wing patterning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Structure-function analysis of Frizzleds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Mathematical modeling of planar cell polarity to understand domineering nonautonomy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Predicting deleterious amino acid substitutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

A role for Xenopus Frizzled 8 in dorsal development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Dishevelled is a component of the frizzled signaling pathway in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

6 June 2018

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Transducing properties of Drosophila Frizzled proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Signaling specificity by Frizzled receptors in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Components of wingless signalling in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512140

18 August 2018

Wnt signalling: the case of the 'missing' G-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23023003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extra tarsal joints and abnormal cuticular polarities in various mutants ofDrosophila melanogaster

1 reference

https://pubmed.ncbi.nlm.nih.gov/23023003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family

1 reference

https://pubmed.ncbi.nlm.nih.gov/23023003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1534/GENETICS.112.144592

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

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