(Q41816900)

English

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

scientific article published on September 15, 1991

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage (English)

1 reference

10.1042/BJ2780715

https://api.crossref.org/works/10.1042/BJ2780715

22 October 2022

0 references

1 reference

10.1042/BJ2780715

https://api.crossref.org/works/10.1042/BJ2780715

22 October 2022

1 reference

10.1042/BJ2780715

https://api.crossref.org/works/10.1042/BJ2780715

22 October 2022

Andrew P Halestrap

1

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

language of work or name

0 references

publication date

1 September 1991

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

15 September 1991

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1654889

22 October 2022

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1654889/?tool=EBI

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1654889

22 October 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1654889/pdf/?tool=EBI

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1654889

22 October 2022

https://europepmc.org/articles/PMC1151405

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1654889

22 October 2022

https://europepmc.org/articles/PMC1151405?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1654889

22 October 2022

https://portlandpress.com/biochemj/article-pdf/278/3/715/604030/bj2780715.pdf

Portable Document Format

1 reference

10.1042/BJ2780715

https://api.crossref.org/works/10.1042/BJ2780715

22 October 2022

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

278 ( Pt 3)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

715-719

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia

1 reference

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Effects of metabolic acidosis on viability of cells exposed to anoxia

1 reference

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The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+.

1 reference

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Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes.

1 reference

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6 June 2018

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

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Mitochondrial glutathione status during Ca2+ ionophore-induced injury to isolated hepatocytes.

1 reference

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Effects of glucagon and Ca2+ on the metabolism of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in isolated rat hepatocytes and plasma membranes

1 reference

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6 June 2018

Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content

1 reference

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A critical appraisal of the association between energy charge and cell damage

1 reference

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Regulation of intracellular pH in the myocardium; relevance to pathology

1 reference

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6 June 2018

Role of Ca2+ in toxic cell killing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

1 reference

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6 June 2018

Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death

1 reference

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6 June 2018

Regulation of citric acid cycle by calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Mechanisms by which mitochondria transport calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Mechanisms and regulation of lactate, pyruvate and ketone body transport across the plasma membrane of mammalian cells and their metabolic consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Calcium and pH in anoxic and toxic injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

6 June 2018

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

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The mechanism of action of FK 506.

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6 June 2018

The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms

1 reference

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6 June 2018

The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

1 reference

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6 June 2018

The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151405

18 August 2018

Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a preformed channel as a structural requirement of carrier-mediated transport

1 reference

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The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beneficial effect of cyclosporine on liver ischemia in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial effect of cyclosporine pretreatment in preventing ischemic damage to the liver in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress. A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on mitochondrial Ca2+-transport and matrix Ca2+ using fura-2-loaded rat heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beneficial effect of pretransplant cyclosporine therapy on recipient rats grafted with a 12-hour cold-stored liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of pH on Ca2+ exchange in ferret heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of glutathione in the retention of Ca2+ by liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

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based on heuristic

inferred from PubMed ID database lookup

Extracellular acidosis protects Ehrlich ascites tumor cells and rat renal cortex against anoxic injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Influence of Changes in pH of the Perfusion Fluid on the Occurrence of the Calcium Paradox in the Isolated Rat Heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of pH on sulfhydryl groups and fluidity of the mitochondrial membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/1654889

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2780715

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

ResearchGate publication ID

0 references

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