(Q41831029)

English

Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators

scientific article published on October 1994

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators (English)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

author name string

L F Lau

1

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

K Pumiglia

2

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Y P Côté

3

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

M B Feinstein

4

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

language of work or name

0 references

publication date

1 October 1994

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

303 ( Pt 2)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

391-400

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

A modification of receptor theory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells: evidence for receptor hydrolysis in thrombin-dependent signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Thrombin receptor agonist peptide induction of mitogenesis in CCL39 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but i

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Thrombin-induced phosphoinositide hydrolysis in platelets. Receptor occupancy and desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Multiple pathways of thrombin-induced platelet activation differentiated by desensitization and a thrombin exosite inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Domains specifying thrombin–receptor interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Exopeptidases in human platelets: an indication for proteolytic modulation of biologically active peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

High and Moderate Affinity Pathways for -Thrombin-Induced Platelet Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Tissue repair by thrombin-derived peptides in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor-activating peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Vascular actions of thrombin receptor peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Molecular cloning of the rat vascular smooth muscle thrombin receptor. Evidence for in vitro regulation by basic fibroblast growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

6 June 2018

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

18 August 2018

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

18 August 2018

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1137340

18 August 2018

Dissociation of thrombin from platelets by hirudin. Evidence for receptor processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity studies of the thrombin receptor activating peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalization and recycling of activated thrombin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the cloned platelet thrombin receptor decreases the pertussis-toxin-dependent ADP-ribosylation of the membrane and soluble inhibitory guanine-nucleotide-binding-alpha proteins. Inhibition by the prostacyclin analog, iloprost

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term effects of thrombin require sustained activation of the functional thrombin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-linking of alpha and gamma-thrombin to distinct binding sites on human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic release of arachidonic acid from platelets by activators of protein kinase C and Ca2+ ionophores. Evidence for the role of protein phosphorylation in the activation of phospholipase A2 and independence from the Na+/H+ exchanger

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The common pathway for alpha- and gamma-thrombin-induced platelet activation is independent of GPIb: a study of Bernard-Soulier platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a nucleotide-binding site on glycoprotein IIb. Relationship to ADP-induced platelet activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Thrombin" receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7526841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3030391

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

ResearchGate publication ID

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