(Q418404)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51681

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

CCR5+membrane1.png
1,240 × 984; 1.25 MB

media legend

Рецептор CCR5 в мембране (Russian)

1 reference

imported from Wikimedia project

Russian Wikipedia

Wikimedia import URL

https://ru.wikipedia.org/?oldid=119257579

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

chemokine (C-C motif) ligand 5 binding

1 reference

16 July 2018

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

IPI

virus receptor activity

1 reference

8 April 2019

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

10 references

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

CXCR4-CCR5: a couple modulating T cell functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

C-C chemokine receptor activity

IPI

5 references

16 July 2018

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

1 reference

8 April 2019

Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

phosphatidylinositol phospholipase C activity

1 reference

8 April 2019

Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

C-C chemokine binding

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

C-C chemokine receptor activity

6 references

8 April 2019

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

C-C chemokine binding

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

chemokine (C-C motif) ligand 5 binding

1 reference

16 July 2018

Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

1 reference

8 April 2019

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

3 references

integral component of plasma membrane

1 reference

8 April 2019

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

external side of plasma membrane

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

16 July 2018

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

external side of plasma membrane

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

G protein-coupled receptor signaling pathway

biological process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

IEP

response to cholesterol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

IMP

1 reference

8 April 2019

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

positive regulation of cytosolic calcium ion concentration

1 reference

16 July 2018

Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51681&geneProductId=UniProtKB:P51681

1 reference

8 April 2019

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

dendritic cell chemotaxis

1 reference

8 April 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

cellular defense response

IEP

1 reference

8 April 2019

Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

cell surface receptor signaling pathway

1 reference

8 April 2019

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

cellular response to lipopolysaccharide

1 reference

8 April 2019

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

IEP

calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

calcium-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

fusion of virus membrane with host plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

chemokine-mediated signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

negative regulation of macrophage apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

3 references

8 April 2019

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

inflammatory response

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

3 references

8 April 2019

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

calcium-mediated signaling

3 references

8 April 2019

Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51681

physically interacts with

1 reference

805

17 August 2016

1 reference

801

17 August 2016

2 references

806

English

17 August 2016

803

17 August 2016

1 reference

807

English

17 August 2016

aplaviroc hydrochloride

object has role

antagonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1668019

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1951914

exact match

http://purl.uniprot.org/uniprot/P51681

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51681

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016