(Q41840986)

English

mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition

scientific article published on 20 July 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Prashanth T Bhaskar

1

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Veronique Nogueira

2

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Krushna C Patra

3

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Sang-Min Jeon

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Youngkyu Park

5

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

R Brooks Robey

6

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Nissim Hay

7

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

language of work or name

0 references

publication date

20 July 2009

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

29

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

18

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

5136-5147

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2738274/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Dissecting eIF4E action in tumorigenesis

1 reference

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6 June 2018

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

1 reference

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6 June 2018

The two TORCs and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

1 reference

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6 June 2018

Tuberous sclerosis complex: a review

1 reference

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6 June 2018

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

1 reference

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Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

1 reference

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Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival.

1 reference

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6 June 2018

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

6 June 2018

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

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6 June 2018

Tuberin activates the proapoptotic molecule BAD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

18 August 2018

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2738274

18 August 2018

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

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18 August 2018

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

1 reference

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18 August 2018

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01946-08

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

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