(Q41849212)

English

Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell

scientific article published on April 1997

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scholarly article

1 reference

Europe PubMed Central

13 October 2017

Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell (English)

1 reference

Europe PubMed Central

13 October 2017

endoplasmic reticulum

0 references

1 reference

based on heuristic

inferred from title

author name string

P C Guest

1

1 reference

Europe PubMed Central

13 October 2017

E M Bailyes

2

1 reference

Europe PubMed Central

13 October 2017

J C Hutton

3

1 reference

Europe PubMed Central

13 October 2017

language of work or name

0 references

publication date

1 April 1997

1 reference

Europe PubMed Central

13 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

13 October 2017

323 ( Pt 2)

1 reference

Europe PubMed Central

13 October 2017

445-450

1 reference

Europe PubMed Central

13 October 2017

The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Posttranslational processing of carboxypeptidase E, a neuropeptide-processing enzyme, in AtT-20 cells and bovine pituitary secretory granules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Mobilization of Ca2+ by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone in permeabilized insulin-secreting RINm5F cells: evidence for separate uptake and release compartments in inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Sorting and processing of secretory proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Transport of Ca2+ and Na+ across the chromaffin-granule membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Inhibition of proteolytic cleavage of the hemagglutinin of influenza virus by the calcium-specific ionophore A23187

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Regulation of insulin release by calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Evidence of beta cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Ca(2+)-induced Ca2+ release in insulin-secreting cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Calcium depletion blocks proteolytic cleavages of plasma protein precursors which occur at the Golgi and/or trans-Golgi network. Possible involvement of Ca(2+)-dependent Golgi endoproteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Defective calcium handling and insulin release in islets from diabetic Chinese hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: A model for altered glucose recognition by the B-cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Calcium distribution in islets of Langerhans: a study of calcium concentrations and of calcium accumulation in B cell organelles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

5 June 2018

Autocatalytic maturation of the prohormone convertase PC2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

18 August 2018

Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218339

18 August 2018

Intracellular Localization of Calcium in Pancreatic B Cells in Relation to Insulin Secretion by the Perfused ob/ob Mouse Pancreas*

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between D-glucose and Ca2+ in the priming of the pancreatic B-cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of calcium localization in pancreatic endocrine cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium exchangeability in subcellular fractions of pancreatic islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of the prohormone convertase PC1(PC3)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of proinsulin conversion in human islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/9163336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3230445

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

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