(Q41852776)

13 October 2017

Hyperammonaemia does not impair brain function in the absence of net glutamine synthesis (English)

1 reference

13 October 2017

R A Hawkins

1

1 reference

PMCID

1151300

13 October 2017

J Jessy

series ordinal

2

1 reference

PMCID

1151300

13 October 2017

language of work or name

English

0 references

publication date

1 August 1991

1 reference

13 October 2017

1 reference

13 October 2017

277 ( Pt 3)

1 reference

13 October 2017

697-703

1 reference

Studies on brain metabolism: The metabolism of glutamic acid in brain

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Methionine sulfoximine prevents the accumulation of large neutral amino acids in brain of hyperammonemic rats

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Nerve endings in methionine sulphoximine convulsant rats, a neurochemical and ultrastructural study.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

A method for the estimation of free and total acid-soluble plasma tryptophan using an ultrafiltration technique

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

The effect of porta-caval anastomosis upon the energy state and upon acid-base parameters of the rat brain.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Effect of hyperammonemia and methionine sulfoximine on the kinetic parameters of blood-brain transport of leucine and phenylalanine.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Methionine sulfoximine prevents the accumulation of large neutral amino acids in brain of portacaval-shunted rats

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Relationship of brain glutamine and brain neutral amino acid concentrations after portacaval anastomosis in rats.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Brain uptake of tryptophan in urease-injected hyperammonemic rats after treatment with benzoate or hippurate.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

The Influence of Ketamine on Regional Brain Glucose Use

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Changes in brain metabolism in hepatic encephalopathy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Ammonia: key factor in the pathogenesis of hepatic encephalopathy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Glutathione metabolism and its selective modification

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Cerebral GABA-ergic and glutamatergic function in hepatic encephalopathy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Biochemistry and physiology of brain ammonia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

L-glutamate stimulates the efflux of newly taken up glutamine from astroglia but not from synaptosomes of the rat.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Failure of glucose and branched-chain amino acids to normalize brain glucose use in portacaval shunted rats.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Early establishment of cerebral dysfunction after portacaval shunting.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Effects of NH4+ on the function of the CNS.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Glucose consumption decreases throughout the brain only hours after portacaval shunting

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Hyperammonaemia depresses glucose consumption throughout the brain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Hyperammonaemia causes many of the changes found after portacaval shunting

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Brain tryptophan, plasma free tryptophan and distribution of plasma neutral amino acids

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Ammonia and Brain Glutamine: Inhibition of Glutamine Degradation by Ammonia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Alzheimer II astrocytosis following methionine sulfoximine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: a possible role of ammonia in brain function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Glutamine--a major substrate for nerve endings.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Ultrastructural study of methionine sulfoximine-induced Alzheimer type II astrocytosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Tryptophan transport across the blood-brain barrier during acute hepatic failure

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

L-Methionine DL-sulphoximine and acute ammonia toxicity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Glutamine Synthetase: Glial Localization in Brain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

EFFECT OF AN INHIBITOR OF GLUTAMINE SYNTHESIS (METHIONINE SULFOXIMINE) ON AMMONIA TOXICITY AND METABOLISM

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Regional blood-brain barrier permeability to amino acids after portacaval anastomosis.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Regional cerebral glucose utilization in rats with portacaval anastomosis.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Ammonia selectively stimulates neutral amino acid transport across blood-brain barrier.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Portacaval anastomosis: brain and plasma metabolite abnormalities and the effect of nutritional therapy.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

In Vivo Release from Cerebral Cortex of [14C]Glutamate Synthesized from [U-14C]Glutamine

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1151300

Significance of glutamic acid for the metabolism of nervous tissue

18 August 2018

1 reference

12 December 2020

Ammonium decreases excitatory synaptic transmission in cat spinal cord in vivo

1 reference

12 December 2020

Inhibition of gamma-glutamylcysteine synthetase by L-methionine-S-sulfoximine

1 reference

12 December 2020

Regional differences in the capacity for ammonia removal by brain following portocaval anastomosis

1 reference

12 December 2020

Increase of Tryptophan and 5-Hydroxyindole Acetic Acid in the Brain of Ornithine Carbamoyltransferase Deficient Sparse-Fur Mice

1 reference

12 December 2020

Control of glutaminase activity in rat brain cortex in vitro: influence of glutamate, phosphate, ammonium, calcium and hydrogen ions

1 reference

12 December 2020

Ammonium ion inhibition of evoked release of endogenous glutamate from hippocampal slices

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ2770697

1 reference

13 October 2017

1 reference

13 October 2017

1 reference

PMCID

1151300