(Q41861087)

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Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

scientific article published on 12 January 2015

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scholarly article

1 reference

Europe PubMed Central

13 October 2017

Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction (English)

1 reference

Europe PubMed Central

13 October 2017

0 references

Reinis Vilskersts

4

1 reference

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7 June 2020

Osvalds Pugovics

10

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7 June 2020

author name string

E Liepinsh

1

1 reference

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7 June 2020

M Makrecka-Kuka

2

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363063%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

J Kuka

3

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7 June 2020

E Makarova

5

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7 June 2020

H Cirule

6

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7 June 2020

E Loza

7

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7 June 2020

D Lola

8

1 reference

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7 June 2020

S Grinberga

9

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7 June 2020

I Kalvins

11

1 reference

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7 June 2020

M Dambrova

12

1 reference

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7 June 2020

language of work or name

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publication date

12 January 2015

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13 October 2017

British Journal of Pharmacology

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7 June 2020

172

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7 June 2020

5

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7 June 2020

1319-1332

1 reference

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7 June 2020

Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase

1 reference

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5 June 2018

The Concise Guide to PHARMACOLOGY 2013/14: transporters

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5 June 2018

The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors

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5 June 2018

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

1 reference

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Troubleshooting digital macro photography for image acquisition and the analysis of biological samples

1 reference

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Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis

1 reference

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5 June 2018

The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine

1 reference

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5 June 2018

Measuring long-chain acyl-coenzyme A concentrations and enrichment using liquid chromatography/tandem mass spectrometry with selected reaction monitoring.

1 reference

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5 June 2018

Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats

1 reference

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5 June 2018

The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion.

1 reference

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5 June 2018

Animal research: reporting in vivo experiments: the ARRIVE guidelines

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5 June 2018

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

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5 June 2018

Modulation of myocardial metabolism: an emerging therapeutic principle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

5 June 2018

The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats

1 reference

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5 June 2018

Myocardial fatty acid metabolism in health and disease

1 reference

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5 June 2018

Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation

1 reference

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5 June 2018

Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats

1 reference

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Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss

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Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

1 reference

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5 June 2018

Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction

1 reference

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5 June 2018

Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes

1 reference

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Metabolic therapy for the treatment of ischemic heart disease: reality and expectations

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5 June 2018

Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

5 June 2018

Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

5 June 2018

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation

1 reference

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5 June 2018

Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

5 June 2018

Mildronate: cardioprotective action through carnitine-lowering effect

1 reference

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5 June 2018

The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

1 reference

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5 June 2018

Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

18 August 2018

Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

18 August 2018

Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337704

18 August 2018

Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice

1 reference

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Effect of inhibiting carnitine biosynthesis on male rat sexual performance.

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TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning

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Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.

1 reference

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18 August 2018

Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat.

1 reference

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18 August 2018

Evolving myocardial infarction in the rat in vivo: an inappropriate model for the investigation of drug-induced infarct size limitation during sustained regional ischaemia.

1 reference

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Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363063

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.13004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363063%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363063%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363063%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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