(Q41874340)

English

Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human

scientific article published on 13 February 2013

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scholarly article

1 reference

Europe PubMed Central

13 October 2017

Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human (English)

1 reference

Europe PubMed Central

13 October 2017

1 reference

based on heuristic

inferred from title

author name string

Dhaval K Shah

1

1 reference

Europe PubMed Central

13 October 2017

Alison M Betts

2

1 reference

Europe PubMed Central

13 October 2017

publication date

13 February 2013

1 reference

Europe PubMed Central

13 October 2017

Monoclonal Antibodies

1 reference

Europe PubMed Central

13 October 2017

5

1 reference

Europe PubMed Central

13 October 2017

2

1 reference

Europe PubMed Central

13 October 2017

297-305

1 reference

Europe PubMed Central

13 October 2017

Pharmacokinetic mAb-mAb interaction: anti-VEGF mAb decreases the distribution of anti-CEA mAb into colorectal tumor xenografts

1 reference

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5 June 2018

Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507.

1 reference

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Imaging of prostate cancer with immuno-PET and immuno-SPECT using a radiolabeled anti-EGP-1 monoclonal antibody

1 reference

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5 June 2018

Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/- mice

1 reference

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Clinical pharmacokinetics of therapeutic monoclonal antibodies

1 reference

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Investigation of the influence of FcRn on the distribution of IgG to the brain

1 reference

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(89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab.

1 reference

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In vitro and in vivo targeting properties of iodine-123- or iodine-131-labeled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model.

1 reference

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Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent

1 reference

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Antibody pharmacokinetics and pharmacodynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

5 June 2018

Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

1 reference

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5 June 2018

Expression of human tumor mucin-associated carbohydrate epitopes, including sialylated Tn, and localization of murine monoclonal antibodies CC49 and B72.3 in a syngeneic rat colon carcinoma model

1 reference

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5 June 2018

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

18 August 2018

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

18 August 2018

Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

18 August 2018

Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers

1 reference

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A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn).

1 reference

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18 August 2018

Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice

1 reference

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18 August 2018

Pharmacokinetic characteristics and biodistribution of radioiodinated chimeric TNT-1, -2, and -3 monoclonal antibodies after chemical modification with biotin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

18 August 2018

Physiologically based pharmacokinetics of cyclosporine A: reevaluation of dose-nonlinear kinetics in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

18 August 2018

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

18 August 2018

Radiolabeled anti-CD45 monoclonal antibodies target lymphohematopoietic tissue in the macaque

1 reference

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18 August 2018

Pharmacokinetics and Tumor Targeting of 131I-Labeled F(ab9)2 Fragments of the Chimeric Monoclonal Antibody G250: Preclinical and Clinical Pilot Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893240

2 December 2018

Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

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inferred from PubMed ID database lookup

Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow dosimetry in rats using direct tissue counting after injection of radio-iodinated intact monoclonal antibodies or F(ab')2 fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics and tissue distribution of the radiolabeled chimeric monoclonal antibody MOv18 IgG and F(ab')2 fragments in ovarian carcinoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of reshaped MAb 425 in three animal species

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of humanized monoclonal anti-IL-13 antibodies with different IL-13 neutralization mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody pharmacokinetics and pharmacodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacologic basis for antibody-auristatin conjugate activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biodistribution of [125I]-labeled therapeutic proteins: application in protein drug development beyond oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/MABS.23684

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

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