(Q41894132)

English

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex

scientific article published on 27 January 2014

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scholarly article

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Europe PubMed Central

13 October 2017

Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex (English)

1 reference

Europe PubMed Central

13 October 2017

1 reference

based on heuristic

inferred from title

computational design

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based on heuristic

inferred from title

1

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2 June 2020

Jose M.m. Caaveiro

2

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2 June 2020

Satoru Nagatoishi

4

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2 June 2020

Makoto Nakakido

5

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2 June 2020

author name string

Eri Miura

3

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2 June 2020

Shinji Soga

6

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2 June 2020

Hiroki Shirai

7

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2 June 2020

Shigeki Kawabata

8

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2 June 2020

Kouhei Tsumoto

9

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2 June 2020

language of work or name

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publication date

27 January 2014

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Europe PubMed Central

13 October 2017

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2 June 2020

9

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2 June 2020

1

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2 June 2020

e87099

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2 June 2020

copyright license

Creative Commons Attribution 4.0 International

27 January 2014

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April 2022 Public Data File from Crossref

copyright status

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Entropy-enthalpy compensation: role and ramifications in biomolecular ligand recognition and design

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Molecular recognition and ligand association

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5 June 2018

Affinity maturation of antibodies: optimized methods to generate high-quality ScFv libraries and isolate IgG candidates by high-throughput screening.

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Computer-aided antibody design

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The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

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Affinity maturation of antibodies assisted by in silico modeling.

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Computational design of antibody-affinity improvement beyond in vivo maturation

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Structural consequences of mutations in interfacial Tyr residues of a protein antigen-antibody complex. The case of HyHEL-10-HEL

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Solution structure and dynamics of the complex between cytochrome c and cytochrome c peroxidase determined by paramagnetic NMR

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5 June 2018

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

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5 June 2018

Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition

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Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8

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Identifiers

10.1371/JOURNAL.PONE.0087099

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2 June 2020

2014PLoSO...987099K

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1 reference

Europe PubMed Central

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2 June 2020

1 reference

Europe PubMed Central

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2 June 2020

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