(Q41895798)

English

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin

scientific article published on March 2003

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scholarly article

1 reference

Europe PubMed Central

13 October 2017

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin (English)

1 reference

Europe PubMed Central

13 October 2017

author name string

Jian Wang

1

1 reference

Europe PubMed Central

13 October 2017

Guohua Chen

2

1 reference

Europe PubMed Central

13 October 2017

Kostas Pantopoulos

3

1 reference

Europe PubMed Central

13 October 2017

language of work or name

0 references

publication date

1 March 2003

1 reference

Europe PubMed Central

13 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

13 October 2017

370

1 reference

Europe PubMed Central

13 October 2017

Pt 3

1 reference

Europe PubMed Central

13 October 2017

891-899

1 reference

Europe PubMed Central

13 October 2017

The hemochromatosis protein HFE inhibits iron export from macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Activation of iron regulatory protein-1 by oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Mechanisms of iron accumulation in hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Combinatorial mRNA regulation: iron regulatory proteins and iso-iron-responsive elements (Iso-IREs).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Genes that modify the hemochromatosis phenotype in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

The transferrin receptor: role in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

A population-based study of the clinical expression of the hemochromatosis gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

The C282Y mutation causing hereditary hemochromatosis does not produce a null allele

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

HFE gene knockout produces mouse model of hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Function and regulation of transferrin and ferritin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

5 June 2018

Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223221

18 August 2018

Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duodenal ferritin synthesis in genetic hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron is hot: an update on the pathophysiology of hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron homeostasis: insights from genetics and animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A population-based study of the biochemical and clinical expression of the H63D hemochromatosis mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A homozygous HFE gene splice site mutation (IVS5+1 G/A) in a hereditary hemochromatosis patient of Vietnamese origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron overload in β2-microglobulin-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12464008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20021607

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

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0 references

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