(Q41919989)

14 October 2017

title

Prooxidant activity of beta-hematin (synthetic malaria pigment) in arachidonic acid micelles and phospholipid large unilamellar vesicles (English)

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ORCID Public Data File 2021

14 October 2017

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author name string

Omodeo-Salè F

1

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14 October 2017

Monti D

2

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14 October 2017

Olliaro P

3

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14 October 2017

Taramelli D

4

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14 October 2017

language of work or name

English

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publication date

1 April 2001

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14 October 2017

published in

Biochemical Pharmacology

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14 October 2017

volume

61

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14 October 2017

issue

8

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14 October 2017

page(s)

999-1009

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Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

14 October 2017

cites work

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An iron-carboxylate bond links the heme units of malaria pigment

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The structure of malaria pigment beta-haematin

7 January 2021

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Transport and trafficking in the malaria-infected erythrocyte

7 January 2021

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Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

7 January 2021

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An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

7 January 2021

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Intraleucocytic malaria pigment and prognosis in severe malaria

7 January 2021

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Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications

7 January 2021

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Interactions of small molecules with phospholipid bilayers. Binding to egg phosphatidylcholine of some organic anions (bromosulphophthalein, oestrone sulphate, haem and bilirubin) that bind to ligandin and aminoazo-dye-binding protein A

7 January 2021

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Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers

7 January 2021

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Mechanism of hemolysis induced by ferriprotoporphyrin IX.

7 January 2021

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Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with heme-proteins by electron spin resonance spectroscopy

7 January 2021

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Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen. A proposed method for P-450 kinetic studies

7 January 2021

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7 January 2021

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7 January 2021

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Malarial pigment (haemozoin): a very active 'inert' substance

7 January 2021

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The heme moiety of malaria pigment (beta-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide-stimulated macrophages

7 January 2021

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Characterization of the products of the heme detoxification pathway in malarial late trophozoites by X-ray diffraction

7 January 2021

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Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by beta-haematin (malaria pigment).

7 January 2021

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7 January 2021

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7 January 2021

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Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine

7 January 2021

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Aggregation of ferrihaems. Dimerization and protolytic equilibria of protoferrihaem and deuteroferrihaem in aqueous solution

7 January 2021

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A simple assay for lipid hydroperoxides based on triphenylphosphine oxidation and high-performance liquid chromatography

7 January 2021

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Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei

7 January 2021

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Kinetics of heme interaction with heme-binding proteins: the effect of heme aggregation state

7 January 2021

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Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX.

7 January 2021

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Lipid oxidation in biological membranes. Electron transfer proteins as initiators of lipid autoxidation

7 January 2021

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Hemin-induced lipid membrane disorder and increased permeability: a molecular model for the mechanism of cell lysis

7 January 2021

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7 January 2021

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7 January 2021

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Partitioning and antioxidant action of the water-soluble antioxidant, Trolox, between the aqueous and lipid phases of phosphatidylcholine membranes: 14C tracer and product studies

7 January 2021

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Effects of additional iron-chelators on Fe(2+)-initiated lipid peroxidation: evidence to support the Fe2+ ... Fe3+ complex as the initiator

7 January 2021

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Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells

7 January 2021

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A novel endogenous antimalarial: Fe(II)-protoporphyrin IX alpha (heme) inhibits hematin polymerization to beta-hematin (malaria pigment) and kills malaria parasites

7 January 2021

1 reference

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On the molecular mechanism of chloroquine's antimalarial action

7 January 2021

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The chemical basis for the ferriprotoporphyrin IX-chloroquine complex induced lipid peroxidation

7 January 2021

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Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

7 January 2021

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Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex

7 January 2021

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Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry

7 January 2021

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Inhibitory effect of chloroquine on the peroxidase activity of ferriprotoporphyrin IX

7 January 2021

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10.1016/S0006-2952(01)00558-5

7 January 2021

Identifiers

DOI

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release_3wlqoadcljerrhk2hzanxw5k7a

14 October 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/3wlqoadcljerrhk2hzanxw5k7a

mapped directly with Wikidata item

24 November 2022

based on heuristic

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