(Q41929003)

English

Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR.

scientific article published on May 2004

In more languages

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scholarly article

1 reference

Europe PubMed Central

14 October 2017

Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR. (English)

1 reference

Europe PubMed Central

14 October 2017

prion protein family

0 references

author name string

Edmond Wong

1

1 reference

Europe PubMed Central

14 October 2017

Alana M Thackray

2

1 reference

Europe PubMed Central

14 October 2017

Raymond Bujdoso

3

1 reference

Europe PubMed Central

14 October 2017

language of work or name

0 references

publication date

1 May 2004

1 reference

Europe PubMed Central

14 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

14 October 2017

380

1 reference

Europe PubMed Central

14 October 2017

Pt 1

1 reference

Europe PubMed Central

14 October 2017

273-282

1 reference

Europe PubMed Central

14 October 2017

Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Dominant-negative inhibition of prion replication in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Molecular features of the copper binding sites in the octarepeat domain of the prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Location and properties of metal-binding sites on the human prion protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

NMR structure of the bovine prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

High yield purification and physico-chemical properties of full-length recombinant allelic variants of sheep prion protein linked to scrapie susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Consequences of manganese replacement of copper for prion protein function and proteinase resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

NMR solution structure of the human prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Normal prion protein has an activity like that of superoxide dismutase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Copper stimulates endocytosis of the prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Reversibility of scrapie inactivation is enhanced by copper.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

The cellular prion protein binds copper in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Recombinant full-length murine prion protein, mPrP(23-231): purification and spectroscopic characterization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

NMR structure of the mouse prion protein domain PrP(121-231)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Novel proteinaceous infectious particles cause scrapie

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

5 June 2018

Structural changes of the prion protein in lipid membranes leading to aggregation and fibrillization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Amyloidogenic unfolding intermediates differentiate sheep prion protein variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Pathway complexity of prion protein assembly into amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Isolation of isoforms of mouse prion protein with PrP(SC)-like structural properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

XAFS study of the high-affinity copper-binding site of human PrP(91-231) and its low-resolution structure in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

On the mechanism of alpha-helix to beta-sheet transition in the recombinant prion protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Folding of prion protein to its native alpha-helical conformation is under kinetic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Cellular prion proteins of mammalian species display an intrinsic partial proteinase K resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Familial mutations and the thermodynamic stability of the recombinant human prion protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Prion protein selectively binds copper(II) ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Physical studies of conformational plasticity in a recombinant prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Estimation of globular protein secondary structure from circular dichroism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

Scrapie prions aggregate to form amyloid-like birefringent rods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

18 August 2018

The cellular prion protein binds copper in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

30 September 2018

Strain-specific prion-protein conformation determined by metal ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224157

2 December 2018

BSE in sheep bred for resistance to infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane environment alters the conformational structure of the recombinant human prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper(II) binding modes in the prion octapeptide PHGGGWGQ: a spectroscopic and voltammetric study

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein binds copper within the physiological concentration range

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper binding to the N-terminal tandem repeat region of mammalian and avian prion protein: structural studies using synthetic peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extremely rapid folding of the C-terminal domain of the prion protein without kinetic intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural mobility of the human prion protein probed by backbone hydrogen exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/14969585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20031767

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

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