(Q41934777)

English

Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.

scientific article published on 23 January 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

1 reference

based on heuristic

inferred from title

author name string

Hsia-lien Lin

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Haoming Zhang

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Paul F Hollenberg

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

0 references

publication date

23 January 2009

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Journal of Pharmacology and Experimental Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

329

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

26-37

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Human CYP2B6: expression, inducibility and catalytic activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

RU486 (mifepristone): mechanisms of action and clinical uses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Acetylenic mechanism-based inhibitors of cholesterol side chain cleavage by cytochrome P-450scc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

How the potency of the steroid RU486 is related to P450 activities induced by dexamethasone and phenobarbital in rat hepatoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Oxidative metabolism and de-ethynylation of 17α-ethynylestradiol by baboon liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

5 June 2018

Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

Antiprogestin-mediated inactivation of cytochrome P450 3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670597

18 August 2018

Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450LM4 (rabbit liver)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shift of the acetylenic hydrogen during chemical and enzymatic oxidation of the biphenylacetylene triple bond

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modified acetylenic steroids as potent mechanism-based inhibitors of cytochrome P-450SCC

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of the antiprogesterone RU 486: no correlation to clinical performance of RU 486

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mass spectrometry in the analysis of glutathione conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inhibition of rat liver microsomal diazepam C3-hydroxylase by mifepristone associated with loss of spectrally detectable cytochrome P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inactivation of cytochrome P450 3A5 by 17alpha-ethynylestradiol is cytochrome b5-dependent: metabolic activation of the ethynyl moiety leads to the formation of glutathione conjugates, a heme adduct, and covalent binding to the apoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19168709

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.108.148536

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

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