(Q4197146)

English

Tumor protein p73

mammalian protein found in Homo sapiens

TP73
tumor protein p73
p53-like transcription factor
p53-related protein
TP73 protein, human

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15350

tumor protein p73

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15350

p53-like tetramerisation domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15350

p53/RUNT-type transcription factor, DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15350

Sterile alpha motif/pointed domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15350

Tumour protein p73, SAM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sterile alpha motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

p53, tetramerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

p53, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

2 references

sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

transcription factor binding

determination method

1 reference

8 April 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

chromatin binding

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

A novel response element confers p63- and p73-specific activation of the WNT4 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

damaged DNA binding

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

protein binding

determination method

15 references

8 April 2019

ASPP1 and ASPP2: common activators of p53 family members

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

MDM2 and MDMX bind and stabilize the p53-related protein p73

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

The ubiquitin-protein ligase Itch regulates p73 stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Differential effect of ik3-1/cables on p53- and p73-induced cell death

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

identical protein binding

determination method

3 references

8 April 2019

Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

protein kinase binding

determination method

determination method

1 reference

8 April 2019

Functional interplay between MDM2, p63/p73 and mutant p53

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

DNA-binding transcription factor activity

determination method

4 references

8 April 2019

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Functional interplay between MDM2, p63/p73 and mutant p53

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

The ubiquitin-protein ligase Itch regulates p73 stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

MDM2/MDM4 family protein binding

determination method

1 reference

8 April 2019

Functional interplay between MDM2, p63/p73 and mutant p53

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

transcription regulator complex

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

biological process

negative regulation of neuron apoptotic process

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

positive regulation of oligodendrocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

negative regulation of neuron differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

kidney development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

cellular response to UV

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

protein tetramerization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

mitotic G1 DNA damage checkpoint signaling

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

response to organonitrogen compound

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

intrinsic apoptotic signaling pathway in response to DNA damage

determination method

1 reference

8 April 2019

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

DNA mismatch repair

determination method

1 reference

8 April 2019

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

negative regulation of cardiac muscle cell proliferation

determination method

1 reference

8 April 2019

Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

negative regulation of JUN kinase activity

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

response to gamma radiation

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

response to X-ray

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

positive regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

A novel response element confers p63- and p73-specific activation of the WNT4 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

negative regulation of cell population proliferation

determination method

1 reference

27 March 2018

Physical and functional interaction between HCV core protein and the different p73 isoforms

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15350&geneProductId=UniProtKB:O15350

determination method

regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

positive regulation of transcription, DNA-templated

determination method

3 references

8 April 2019

Functional interplay between MDM2, p63/p73 and mutant p53

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

A novel response element confers p63- and p73-specific activation of the WNT4 promoter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

8 April 2019

The ubiquitin-protein ligase Itch regulates p73 stability

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

regulation of hematopoietic stem cell differentiation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15350

determination method

Gene Atlas image

PBB GE TP73 220804 s at fs.png
732 × 530; 12 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

TP73 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000475143

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000475143

ENSP00000340740

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340740

ENSP00000346423

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000346423

ENSP00000350366

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000350366

ENSP00000367534

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367534

ENSP00000367537

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367537

ENSP00000367539

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367539

ENSP00000367545

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367545

ENSP00000474322

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000474322

ENSP00000474626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000474626

ENSP00000367529

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367529

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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