(Q41994180)

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Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

scientific article published on November 1999

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2 November 2019

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX (English)

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2 November 2019

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Giovanni Lentini

4

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2 November 2019

Jean-François Desaphy

1

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2 November 2019

Annamaria De Luca

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2 November 2019

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D Conte Camerino

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2 November 2019

V Tortorella

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2 November 2019

C Franchini

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2 November 2019

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1 November 1999

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2 November 2019

British Journal of Pharmacology

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2 November 2019

128

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2 November 2019

6

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2 November 2019

1165-1174

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2 November 2019

Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics

1 reference

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5 June 2018

Effects of temperature and mexiletine on the F1473S Na+ channel mutation causing paramyotonia congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin

1 reference

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5 June 2018

Sodium channel selectivity filter regulates antiarrhythmic drug binding

1 reference

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5 June 2018

A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

From mutation to myotonia in sodium channel disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Use-dependent block of Na+ currents by mexiletine at the single channel level in guinea-pig ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Amine blockers of the cytoplasmic mouth of sodium channels: a small structural change can abolish voltage dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Comparatibe actions of mexiletine on sodium channels in nerve, skeletal and cardiac muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

The site of action and active form of local anesthetics. II. Experiments with quaternary compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Why do some drugs preferentially block open sodium channels?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Localization of the receptor site for alpha-scorpion toxins by antibody mapping: implications for sodium channel topology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrhythmic drug receptor on rat cardiac myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Stereoselective interaction of tocainide and its chiral analogs with the sodium channels in human myoballs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

5 June 2018

Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

18 August 2018

The familial periodic paralyses and nondystrophic myotonias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

18 August 2018

Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

18 August 2018

Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

18 August 2018

Loss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

18 August 2018

Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571747

18 August 2018

Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10578128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10578128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10578128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10578128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10578128

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0702901

1 reference

Europe PubMed Central

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2 November 2019

PMC publication ID

1 reference

Europe PubMed Central

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2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10578128%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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