(Q42002364)

English

Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

scientific article published on 18 March 2008

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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6 January 2020

author name string

Seho Kim

2

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Europe PubMed Central

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6 January 2020

David A Fela

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Jean Baum

4

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6 January 2020

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publication date

18 March 2008

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6 January 2020

number of pages

12

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Journal of Molecular Biology

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6 January 2020

378

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6 January 2020

5

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Europe PubMed Central

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6 January 2020

1104-1115

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

NMR View: A computer program for the visualization and analysis of NMR data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein

1 reference

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5 June 2018

Residual structure, backbone dynamics, and interactions within the synuclein family

1 reference

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5 June 2018

Atomic-level characterization of disordered protein ensembles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

1 reference

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5 June 2018

Characterization of the unfolded state of bovine alpha-lactalbumin and comparison with unfolded states of homologous proteins

1 reference

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5 June 2018

Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation

1 reference

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5 June 2018

Unfolded proteins and protein folding studied by NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

The Xplor-NIH NMR molecular structure determination package

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

GFT NMR, a new approach to rapidly obtain precise high-dimensional NMR spectral information.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Protein dynamics in supercooled water: the search for slow motional modes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Use of chemical shifts in macromolecular structure determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Aromatic ring-flipping in supercooled water: implications for NMR-based structural biology of proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

NMR spectroscopy: a multifaceted approach to macromolecular structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Alpha-synuclein in Lewy bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

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Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

5 June 2018

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

18 August 2018

Short-range, long-range and transition state interactions in the denatured state of ACBP from residual dipolar couplings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064448

18 August 2018

Role of protein-water interactions and electrostatics in alpha-synuclein fibril formation.

1 reference

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18 August 2018

GFT NMR experiments for polypeptide backbone and 13Cbeta chemical shift assignment

1 reference

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The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation

1 reference

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1 reference

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1 reference

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18 August 2018

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1 reference

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

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Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

1 reference

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2 December 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18423664

12 December 2020

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inferred from PubMed ID database lookup

Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18423664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Characterization of the Intrinsically Unfolded Protein β-Synuclein, a Natural Negative Regulator of α-Synuclein Aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18423664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18423664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2008.03.017

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18423664%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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