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Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
scientific article published on 12 May 2014
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scholarly article
1 reference
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
title
Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
author
Thomas Jentsch
series ordinal
6
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Europe PubMed Central
PMC publication ID
4196982
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Sabrina Jabs
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2
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
author name string
Stefanie Weinert
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1
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PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Svea Hohensee
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3
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PMC publication ID
4196982
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Wing Lee Chan
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4
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Uwe Kornak
series ordinal
5
1 reference
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
publication date
12 May 2014
1 reference
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
published in
EMBO Reports
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PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
volume
15
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
issue
7
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stated in
Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
page(s)
784-791
1 reference
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Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
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A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle
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Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+ exchanger ClC-7/Ostm1.
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ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity
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ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function
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Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene
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Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man
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Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.
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ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family
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CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals
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Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis
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Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.
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ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.
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CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology
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2 December 2018
Identifiers
DOI
10.15252/EMBR.201438553
1 reference
stated in
Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
PMC publication ID
4196982
1 reference
stated in
Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
PubMed publication ID
24820037
1 reference
stated in
Europe PubMed Central
PMC publication ID
4196982
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24820037%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
ResearchGate publication ID
262269555
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