(Q42026029)

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The role of ovarian sex steroids in metabolic homeostasis, obesity, and postmenopausal breast cancer: molecular mechanisms and therapeutic implications.

scientific article published on 19 March 2015

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5 March 2020

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The role of ovarian sex steroids in metabolic homeostasis, obesity, and postmenopausal breast cancer: molecular mechanisms and therapeutic implications (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25866757%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

7 references

19 March 2019

24 March 2019

19 June 2019

9 October 2019

10 October 2019

13 November 2019

17 November 2019

genitourinary system

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9 October 2019

endocrine system

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10 October 2019

polycyclic compound

1 reference

13 November 2019

1 reference

17 November 2019

Viroj Boonyaratanakornkit

1

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5 March 2020

Prangwan Pateetin

2

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5 March 2020

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Viroj Boonyaratanakornkit

1

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15 October 2017

Prangwan Pateetin

2

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15 October 2017

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19 March 2015

8 references

19 March 2019

24 March 2019

19 June 2019

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17 November 2019

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5 March 2020

BioMed Research International

8 references

19 March 2019

24 March 2019

19 June 2019

9 October 2019

10 October 2019

13 November 2019

17 November 2019

Europe PubMed Central

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5 March 2020

2015

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5 March 2020

140196

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5 March 2020

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Creative Commons Attribution 3.0 Unported

7 references

Europe PubMed Central

19 March 2019

Europe PubMed Central

24 March 2019

Europe PubMed Central

19 June 2019

Europe PubMed Central

9 October 2019

Europe PubMed Central

10 October 2019

Europe PubMed Central

13 November 2019

Europe PubMed Central

17 November 2019

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0 references

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Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable

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Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer

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Estrogen receptors and the metabolic network

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Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

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Increased estrogen receptor β in adipose tissue is associated with increased intracellular and reduced circulating adiponectin protein levels in aged female rats

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5 June 2018

Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer

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5 June 2018

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor

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Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

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Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells

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5 June 2018

Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer

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Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis

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Metabolic impact of sex hormones on obesity

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

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A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats

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Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging

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Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors

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Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue

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Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease

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Effects of ovarian hormones on exercise metabolism

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Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases

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Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice.

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Increased adipose tissue in male and female estrogen receptor-alpha knockout mice

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Steroid hormone receptors: an update

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Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus

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Estrogen increases in vivo leptin production in rats and human subjects

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Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

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5 June 2018

Progesterone receptor (PR) inhibits expression of insulin-like growth factor-binding protein-1 (IGFBP-1) in human endometrial cell line HEC-1B: characterization of the inhibitory effect of PR on the distal promoter region of the IGFBP-1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Aromatase activity in adipose tissue from breast quadrants: a link with tumour site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

The effect of pre-morbid height and weight on the survival of breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Rat brain glycolysis regulation by estradiol-17 beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Tamoxifen induced changes in MCF7 human breast cancer: in vitro and in vivo studies using nuclear magnetic resonance spectroscopy and imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

5 June 2018

Estradiol-17β upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-α and to integrate metabolic reprogramming with the mitogenic response in endometrial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Estradiol in vivo regulation of brain mitochondrial proteome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Ultrastructural localization of estrogen receptor beta immunoreactivity in the rat hippocampal formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Effect of ovariectomy and estradiol replacement on skeletal muscle enzyme activity in female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4383469

17 August 2018

Gestational Diabetes Mellitus

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F140196

21 January 2018

Metabolic syndrome and the risk of breast cancer in postmenopausal women

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F140196

21 January 2018

Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F140196

21 January 2018

Estrogen induces accumulation of the mitochondrial ribonucleic acid for subunit II of cytochrome oxidase in pituitary tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-activated progesterone receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 (insulin-like growth factor binding protein-1) in human endometrial stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of 17beta-estradiol and/or progesterone on insulin sensitivity in the rat: implications during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of obesity on US mortality levels: the importance of age and cohort factors in population estimates

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/25866757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2015/140196

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25866757%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25866757%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25866757%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

ResearchGate publication ID

0 references

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