(Q42029205)

English

Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles.

scientific article published on 17 January 2012

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22252449%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22252449%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Jeffrey Teckman

5

1 reference

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20 January 2020

Phillip D. Zamore

7

1 reference

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20 January 2020

author name string

Christian Mueller

1

1 reference

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20 January 2020

Qiushi Tang

2

1 reference

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20 January 2020

Alisha Gruntman

3

1 reference

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20 January 2020

Keith Blomenkamp

4

1 reference

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20 January 2020

Lina Song

6

1 reference

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20 January 2020

Terence R Flotte

8

1 reference

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20 January 2020

publication date

17 January 2012

1 reference

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20 January 2020

Molecular Therapy

1 reference

Europe PubMed Central

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20 January 2020

20

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20 January 2020

3

1 reference

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20 January 2020

590-600

1 reference

Europe PubMed Central

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20 January 2020

Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins

1 reference

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5 June 2018

Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response

1 reference

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5 June 2018

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.

1 reference

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5 June 2018

Alpha-1-antitrypsin deficiency: importance of proteasomal and autophagic degradative pathways in disposal of liver disease-associated protein aggregates

1 reference

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5 June 2018

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

1 reference

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5 June 2018

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

1 reference

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5 June 2018

Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects

1 reference

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5 June 2018

Essential role for Argonaute2 protein in mouse oogenesis

1 reference

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5 June 2018

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Collapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in Flies

1 reference

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5 June 2018

Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo

1 reference

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5 June 2018

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

1 reference

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5 June 2018

Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model.

1 reference

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5 June 2018

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

1 reference

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5 June 2018

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway

1 reference

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5 June 2018

In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Processing of primary microRNAs by the Microprocessor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

In situ synthesis of oligonucleotide microarrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

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5 June 2018

Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice

1 reference

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5 June 2018

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

5 June 2018

Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

17 August 2018

Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

17 August 2018

Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

17 August 2018

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3293602

2 December 2018

Prevalence of hepatocellular carcinoma in alpha-1-antitrypsin deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/22252449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Argonaute proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22252449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MT.2011.292

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22252449%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22252449%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22252449%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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