(Q42048818)

English

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

scientific article published on 19 March 2007

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scholarly article

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Europe PubMed Central

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27 December 2019

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations (English)

1 reference

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27 December 2019

Aspergillus fumigatus

0 references

14-alpha sterol demethylase

1 reference

6 February 2019

Putative 14-alpha demethylase with a predicted role in ergosterol biosynthesis

1 reference

6 February 2019

1

1 reference

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27 December 2019

Willem Melchers

4

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27 December 2019

Paul E. Verweij

5

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27 December 2019

author name string

G Garcia-Effron

2

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27 December 2019

L Alcázar-Fuoli

3

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27 December 2019

M Cuenca-Estrella

6

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27 December 2019

J L Rodríguez-Tudela

7

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27 December 2019

language of work or name

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publication date

19 March 2007

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27 December 2019

number of pages

8

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inferred from page(s)

Antimicrobial Agents and Chemotherapy

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27 December 2019

51

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27 December 2019

6

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27 December 2019

1897-1904

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27 December 2019

Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.

1 reference

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5 June 2018

Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

1 reference

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The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus

1 reference

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Current approaches to diagnosis and treatment of invasive aspergillosis

1 reference

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5 June 2018

Use of a novel panel of nine short tandem repeats for exact and high-resolution fingerprinting of Aspergillus fumigatus isolates

1 reference

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5 June 2018

Aspergillus fumigatus: saprophyte or pathogen?

1 reference

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5 June 2018

Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

1 reference

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5 June 2018

Multidrug resistance in yeast Candida

1 reference

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5 June 2018

In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance

1 reference

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5 June 2018

Voriconazole: therapeutic review of a new azole antifungal

1 reference

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5 June 2018

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

1 reference

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5 June 2018

Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

1 reference

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5 June 2018

Interlaboratory evaluation of hematocytometer method of inoculum preparation for testing antifungal susceptibilities of filamentous fungi

1 reference

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5 June 2018

Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis

1 reference

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5 June 2018

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

1 reference

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5 June 2018

A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891382

5 June 2018

Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891382

5 June 2018

Population genomics of drug resistance in Candida albicans.

1 reference

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5 June 2018

Invasive aspergillosis in 2002: an update

1 reference

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5 June 2018

Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

1 reference

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5 June 2018

Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance P

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891382

5 June 2018

Azole cross-resistance in Aspergillus fumigatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891382

5 June 2018

Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891382

5 June 2018

Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA.

1 reference

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5 June 2018

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

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5 June 2018

Inoculum standardization for antifungal susceptibility testing of filamentous fungi pathogenic for humans

1 reference

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Aspergillosis case-fatality rate: systematic review of the literature

1 reference

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5 June 2018

Tandem repeat of a transcriptional enhancer upstream of the sterol 14alpha-demethylase gene (CYP51) in Penicillium digitatum

1 reference

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In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole

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5 June 2018

Aspergillus fumigatus and aspergillosis

1 reference

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5 June 2018

Comparison of the in-vitro activity of voriconazole (UK-109,496), itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus

1 reference

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5 June 2018

Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

1 reference

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Molecular biological characterization of an azole-resistant Candida glabrata isolate

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A mutation in the 14 alpha-demethylase gene of Uncinula necator that correlates with resistance to a sterol biosynthesis inhibitor

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5 June 2018

Itraconazole resistance in Aspergillus fumigatus

1 reference

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Increased resistance to 14 alpha-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14 alpha-demethylase (cyp51) and the A. niger cytochrome P450 reductase (cprA) genes

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The 14alpha-Demethylasse(CYP51A1) Gene is Overexpressed in Venturia inaequalis Strains Resistant to Myclobutanil

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Overexpression of the 14alpha-demethylase target gene (CYP51) mediates fungicide resistance in Blumeriella jaapii

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Sequence variation in the CYP51 gene of Blumeria graminis associated with resistance to sterol demethylase inhibiting fungicides

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Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma

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Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

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17 August 2018

Multiple amino acid substitutions in lanosterol 14alpha-demethylase contribute to azole resistance in Candida albicans.

1 reference

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17 August 2018

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.

1 reference

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17 August 2018

PCR cloning and detection of point mutations in the eburicol 14alpha-demethylase (CYP51) gene from Erysiphe graminis f. sp. hordei, a "recalcitrant" fungus.

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Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine 5'-monophosphate decarboxylase.

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17 August 2018

The genetics of Aspergillus nidulans

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17371828

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro susceptibility of respiratory isolates of Aspergillus species to itraconazole and amphotericin B. acquired resistance to itraconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/17371828

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-Triazole–Resistant Aspergillosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17371828

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.01092-06

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17371828%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17371828%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17371828%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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