(Q42063999)

15 October 2017

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors (English)

1 reference

15 October 2017

0 references

Kristin E D Coan

1

1 reference

PMCID

2627561

15 October 2017

Brian K Shoichet

series ordinal

2

1 reference

PMCID

2627561

15 October 2017

language of work or name

English

0 references

publication date

28 June 2008

1 reference

Journal of the American Chemical Society

15 October 2017

7

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

15 October 2017

130

1 reference

15 October 2017

29

1 reference

15 October 2017

9606-9612

1 reference

Small-molecule aggregates inhibit amyloid polymerization

15 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

A detergent-based assay for the detection of promiscuous inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Targeting proteases: successes, failures and future prospects

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Avoiding physicochemical artefacts in early ADME-Tox experiments

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Hit discovery and hit-to-lead approaches

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

High-throughput assays for promiscuous inhibitors.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Pursuing the leadlikeness concept in pharmaceutical research.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

A specific mechanism of nonspecific inhibition

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Effect of detergent on "promiscuous" inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Kinase inhibitors: not just for kinases anymore

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Nonleadlikeness and leadlikeness in biochemical screening

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Molecular properties that influence the oral bioavailability of drug candidates

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Development of a virtual screening method for identification of "frequent hitters" in compound libraries

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Specificity and mechanism of action of some commonly used protein kinase inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Recognizing molecules with drug-like properties

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

A high-throughput screen for aggregation-based inhibition in a large compound library.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Stability and equilibria of promiscuous aggregates in high protein milieus.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Interpreting steep dose-response curves in early inhibitor discovery

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Inhibition of kinesin motor proteins by adociasulfate-2.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Detailed kinetic studies of an aggregating inhibitor; inhibition of phosphomannomutase/phosphoglucomutase by disperse blue 56.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2627561

Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18588298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18588298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA802977H

1 reference

15 October 2017

1 reference

15 October 2017

1 reference

PMCID

2627561