(Q42069114)

English

Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance.

scientific article published on 9 March 2017

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scholarly article

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5 April 2020

Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance (English)

1 reference

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5 April 2020

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Jeremy F Brooks

3

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5 April 2020

Raymond J Steptoe

7

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5 April 2020

author name string

Kunal H Bhatt

1

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5 April 2020

Rajeev Rudraraju

2

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5 April 2020

Ji-Won Jung

4

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5 April 2020

Ryan Galea

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5 April 2020

James W Wells

6

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5 April 2020

publication date

9 March 2017

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5 April 2020

Stem Cell Research & Therapy

1 reference

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5 April 2020

8

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5 April 2020

1

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5 April 2020

57

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5 April 2020

https://scigraph.springernature.com/pub.10.1186/s13287-017-0508-3

0 references

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection

1 reference

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5 June 2018

Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells

1 reference

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5 June 2018

Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients.

1 reference

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5 June 2018

Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.

1 reference

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5 June 2018

Haematopoietic stem cells require a highly regulated protein synthesis rate

1 reference

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5 June 2018

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

1 reference

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5 June 2018

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

1 reference

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5 June 2018

Development of gene therapy for blood disorders: an update

1 reference

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5 June 2018

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Induction of antigen-specific tolerance through hematopoietic stem cell-mediated gene therapy: the future for therapy of autoimmune disease?

1 reference

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5 June 2018

Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Regulatory T cells in γ irradiation-induced immune suppression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Regulation and function of mTOR signalling in T cell fate decisions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Induction of tolerance to factor VIII by transient co-administration with rapamycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Enhancement of antigen-specific Treg vaccination in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Homeostatic proliferation and survival of naïve and memory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Rapamycin and mTOR kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Transcriptional mechanisms underlying lymphocyte tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Immunopharmacology of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

T cell receptor antagonist peptides induce positive selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

5 June 2018

Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A.

1 reference

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17 August 2018

Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Transplantation of retrovirally transduced bone marrow prevents autoimmune disease in aged mice by peripheral tolerance mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Persistence of antigen is required to maintain transplantation tolerance induced by genetic modification of bone marrow stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Low-dose radiation plus rapamycin promotes long-term bone marrow chimerism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Donor hematopoietic cells from transgenic mice that express GFP are immunogenic in immunocompetent recipients.

1 reference

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17 August 2018

Transient gain of effector function by CD8+ T cells undergoing peripheral tolerance to high-dose self-antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

1 reference

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17 August 2018

Induction of cytotoxic T lymphocyte and antibody responses to enhanced green fluorescent protein following transplantation of transduced CD34(+) hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345164

17 August 2018

Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses

1 reference

https://api.crossref.org/works/10.1186%2FS13287-017-0508-3

21 January 2018

Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection

1 reference

https://pubmed.ncbi.nlm.nih.gov/28279220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of T-cell growth by IL-2 and IL-15

1 reference

https://pubmed.ncbi.nlm.nih.gov/28279220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28279220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4+ T Cells Pass Through an Effector Phase During the Process of In Vivo Tolerance Induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/28279220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stem cell transplantation in the normal nonmyeloablated host: relationship between cell dose, schedule, and engraftment

1 reference

https://pubmed.ncbi.nlm.nih.gov/28279220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of bone marrow transduced to express self-antigen establishes deletional tolerance and permanently remits autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28279220

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S13287-017-0508-3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28279220%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s13287-017-0508-3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28279220%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28279220%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

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