(Q42071926)

English

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.

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Europe PubMed Central

PMC publication ID

16 October 2017

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi. (English)

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

1 reference

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Miles D. Houslay

3

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

author name string

Gawler D

1

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Europe PubMed Central

PMC publication ID

16 October 2017

Milligan G

2

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Europe PubMed Central

PMC publication ID

16 October 2017

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publication date

1 January 1988

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Europe PubMed Central

PMC publication ID

16 October 2017

Biochemical Journal

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Europe PubMed Central

PMC publication ID

16 October 2017

249

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Europe PubMed Central

PMC publication ID

16 October 2017

2

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

537-542

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

Is the receptor-mediated endocytosis of cholera toxin A pre-requisite for its activation of adenylate cyclase in intact rat hepatocytes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Membrane structural/functional properties of adipocytes from normal and streptozotocin-diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

G proteins and dual control of adenylate cyclase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Purification and properties of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Islet-activating protein blocks glucagon desensitization in intact hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Interactions of Metabolism and the Physiological Role of Insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Primary structure of the alpha-subunit of transducin and its relationship to ras proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Insulin stimulates a novel GTPase activity in human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver. Twenty-second Colworth medal lecture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Postreceptor effect of metformin on insulin action in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Changes in the guanine nucleotide-binding proteins, Gi and Go, during differentiation of 3T3-L1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Metformin: a review of its pharmacological properties and therapeutic use

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Studies on alpha-adrenergic activation of hepatic glucose output. Insulin inhibition of alpha-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

5 June 2018

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

3 July 2018

The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

3 July 2018

Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

17 August 2018

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1148735

1 December 2018

Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell signalling: Dual control of adenylate cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Guanine Nucleotides and Divalent Cations on Forskolin Activation of Rabbit Luteal Adenylyl Cyclase: Evidence for the Existence of an Inhibitory Guanine Nucleotide-Binding Regulatory Component*

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of adrenergic mechanism from an alpha- to a beta-type during primary culture of rat hepatocytes. Accompanying decreases in the function of the inhibitory guanine nucleotide regulatory component of adenylate cyclase identified as the subst

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP-dependent protein kinase and lipolysis in rat adipocytes. III. Multiple modes of insulin regulation of lipolysis and regulation of insulin responses by adenylate cyclase regulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of insulin on adenosine 3',5'-monophosphate in the rat epididymal fat pad

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholera toxin does not impair hormonal inhibition of adenylate cyclase and concomitant stimulation of a GTPase in adipocyte membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3124829

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2490537

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

release_ic3lx3fzurck5pbjd4bpt73t2a

1 reference

https://api.fatcat.wiki/v0/release/ic3lx3fzurck5pbjd4bpt73t2a

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 October 2017

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