(Q42110554)

English

Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

scientific article published on 27 February 2012

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scholarly article

1 reference

Europe PubMed Central

16 October 2017

Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice (English)

1 reference

Europe PubMed Central

16 October 2017

0 references

1 reference

based on heuristic

inferred from title

author name string

Alexander Rodriguez Guerrero

1

1 reference

Europe PubMed Central

16 October 2017

Kenzo Uchida

2

1 reference

Europe PubMed Central

16 October 2017

Hideaki Nakajima

3

1 reference

Europe PubMed Central

16 October 2017

Shuji Watanabe

4

1 reference

Europe PubMed Central

16 October 2017

Masaya Nakamura

5

1 reference

Europe PubMed Central

16 October 2017

William Eb Johnson

6

1 reference

Europe PubMed Central

16 October 2017

Hisatoshi Baba

7

1 reference

Europe PubMed Central

16 October 2017

publication date

27 February 2012

1 reference

Europe PubMed Central

16 October 2017

Journal of Neuroinflammation

1 reference

Europe PubMed Central

16 October 2017

9

1 reference

Europe PubMed Central

16 October 2017

40

1 reference

Europe PubMed Central

16 October 2017

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-40

0 references

Repertoire of microglial and macrophage responses after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Interferon-γ decreases chondroitin sulfate proteoglycan expression and enhances hindlimb function after spinal cord injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Guidance molecules in axon regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Macrophage polarization to a unique phenotype driven by B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Overcoming macrophage-mediated axonal dieback following CNS injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Macrophages and inflammatory mediators in chemical toxicity: a battle of forces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Macrophages promote axon regeneration with concurrent neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Exploring the full spectrum of macrophage activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Neural stem cells and regeneration of injured spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Inflammatory-mediated injury and repair in the traumatically injured spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

The chemokine system in diverse forms of macrophage activation and polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Regulation of macrophage activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Post-traumatic inflammation following spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Alternative activation of macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Miracles and molecules--progress in spinal cord repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Targeting the host inflammatory response in traumatic spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Interleukin-6 expression and regulation in astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Innate and adaptive immune responses can be beneficial for CNS repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Physiological and pathological roles of interleukin-6 in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Flow cytometric identification of murine neutrophils and monocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Interleukin-6 family of cytokines and gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

29 May 2018

Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

16 June 2018

Tumor necrosis factor-α antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

"Tissue-repairing" blood-derived macrophages are essential for healing of the injured spinal cord: from skin-activated macrophages to infiltrating blood-derived cells?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Interleukin-4 production by human alveolar macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Microglia and macrophages as innate producers of interferon-gamma in the brain following infection with Toxoplasma gondii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Human neutrophils produce interferon gamma upon stimulation by interleukin-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Features of skin-coincubated macrophages that promote recovery from spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine-5'-triphosphatase and superoxide dismutase activation, and ultr

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Effects of pro-inflammatory cytokines in experimental spinal cord injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Tissue distribution, structural characterization, and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3310810

17 August 2018

Neuroprotective effect of vaccination with autoantigen-pulsed dendritic cells after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute inflammatory response in spinal cord following impact injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 production by human polymorphonuclear neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive changes in neurofilament proteins and growth-associated protein-43 immunoreactivities at the site of cervical spinal cord compression in spinal hyperostotic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of anti-mouse interleukin-6 receptor antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental modeling of spinal cord injury: characterization of a force-defined injury device

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colony-stimulating factors as promoters of ameboid microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of neutrophils in spinal cord injury in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22369693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-9-40

1 reference

Europe PubMed Central

16 October 2017

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-40

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

ResearchGate publication ID

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