(Q42112211)

16 October 2017

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives (English)

1 reference

16 October 2017

0 references

1 reference

ChEBI release 2020-05-28

1 reference

6

1 reference

Dolores Gonzalez-Pacanowska

16 October 2017

0 references

author name string

Marco Sealey-Cardona

1

1 reference

16 October 2017

Simon Cammerer

2

1 reference

16 October 2017

Simon Jones

3

1 reference

16 October 2017

Luis M Ruiz-Pérez

4

1 reference

16 October 2017

Reto Brun

5

1 reference

16 October 2017

Julio A Urbina

7

1 reference

16 October 2017

Dolores González-Pacanowska

8

1 reference

16 October 2017

language of work or name

English

0 references

publication date

19 March 2007

1 reference

Antimicrobial Agents and Chemotherapy

16 October 2017

1 reference

16 October 2017

51

1 reference

16 October 2017

6

1 reference

16 October 2017

2123-2129

1 reference

In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Specific chemotherapy of Chagas disease: controversies and advances

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Cloning and expression of squalene synthase cDNA from hot pepper (Capsicum annuum L.).

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Chemotherapy of Chagas disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Detection of live Trypanosoma cruzi in tissues of infected mice by using histochemical stain for beta-galactosidase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Truncation of human squalene synthase yields active, crystallizable protein

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Molecular cloning, in vitro expression and characterization of a plant squalene synthetase cDNA.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Cloning, expression, and characterization of cDNAs encoding Arabidopsis thaliana squalene synthase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Molecular cloning and characterization of the yeast gene for squalene synthetase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Molecular cloning, expression, and characterization of the cDNA for the rat hepatic squalene synthase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

cDNA cloning of squalene synthase genes from mono- and dicotyledonous plants, and expression of the gene in rice

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1891404

Sterol biosynthesis inhibitors: potential chemotherapeutics against Chagas disease

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17371809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17371809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17371809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.01454-06

1 reference

16 October 2017

1 reference

16 October 2017

PubMed publication ID

17371809

1 reference