(Q42117338)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28410221%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Discovery and characterization of small molecule Rac1 inhibitors (English)

1 reference

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17 March 2020

6

1 reference

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17 March 2020

Amarnath Natarajan

9

1 reference

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17 March 2020

author name string

Jamie L Arnst

1

1 reference

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17 March 2020

Ashley L Hein

2

1 reference

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17 March 2020

Margaret A Taylor

3

1 reference

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17 March 2020

Nick Y Palermo

4

1 reference

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17 March 2020

Jacob I Contreras

5

1 reference

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17 March 2020

Andrew O Wahl

7

1 reference

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17 March 2020

Michel M Ouellette

8

1 reference

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17 March 2020

Ying Yan

10

1 reference

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17 March 2020

language of work or name

English

0 references

publication date

1 May 2017

1 reference

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17 March 2020

1 reference

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17 March 2020

volume

8

1 reference

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17 March 2020

issue

21

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17 March 2020

page(s)

34586-34600

1 reference

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describes a project that uses

17 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5470993/fullTextXML

inferred from PubMed Central ID database lookup

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29 May 2018

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Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein

29 May 2018

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29 May 2018

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29 May 2018

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Virtual screening approach for the identification of new Rac1 inhibitors

29 May 2018

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Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement

29 May 2018

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Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat

29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

29 May 2018

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Structural Basis of the Rho GTPase Signaling

29 May 2018

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29 May 2018

1 reference

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Tumour-cell invasion and migration: diversity and escape mechanisms

29 May 2018

1 reference

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29 May 2018

RHO-GTPases and cancer

1 reference

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Immortalization with telomerase of the Nestin-positive cells of the human pancreas

29 May 2018

1 reference

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Rho GTPases in cell biology

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Dbl family guanine nucleotide exchange factors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Gene expression profiles of pancreatic cancer and stromal desmoplasia

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Rho GTPases and their effector proteins

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Rac1 is required for cell proliferation and G2/M progression.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

An essential role for Rac in Ras transformation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Comparative functional analysis of the Rac GTPases

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Phase II study of gemcitabine combined with radiation therapy in patients with localized, unresectable pancreatic cancer

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470993

Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein

17 August 2018

1 reference

12 December 2020

Prognostic relevance of increased Rac GTPase expression in prostate carcinomas

1 reference

12 December 2020

Balanced Tiam1-rac1 and RhoA drives proliferation and invasion of pancreatic cancer cells

1 reference

12 December 2020

Role of radiation therapy in the management of locally advanced pancreatic cancer

1 reference

12 December 2020

The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

1 reference

12 December 2020

Rac1 takes center stage in pancreatic cancer and ulcerative colitis: quantity matters

1 reference

12 December 2020

10.18632/ONCOTARGET.16656

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28410221%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28410221%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

28410221

1 reference