(Q42141122)

17 October 2017

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells (English)

1 reference

17 October 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Luca Marchetti

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Simona Polo

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Alexia Conte

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Elisabetta Argenzio

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Corrado Priami

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Pier Paolo Di Fiore

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Sara Sigismund

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Andrea Ciliberto

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

12 August 2015

1 reference

17 October 2017

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

7999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

31 May 2020

copyright license

start time

12 August 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms8999

0 references

cites work

Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation

1 reference

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When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

29 May 2018

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Threshold-controlled ubiquitination of the EGFR directs receptor fate

29 May 2018

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Conformational coupling across the plasma membrane in activation of the EGF receptor

29 May 2018

1 reference

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Governance of endocytic trafficking and signaling by reversible ubiquitylation

29 May 2018

1 reference

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Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics

29 May 2018

1 reference

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Computational analysis of the regulation of EGFR by protein tyrosine phosphatases

29 May 2018

1 reference

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Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

29 May 2018

1 reference

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Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

29 May 2018

1 reference

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Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

29 May 2018

1 reference

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Detecting mycoplasma contamination in cell cultures by polymerase chain reaction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Cell signaling by receptor tyrosine kinases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Spatial control of EGF receptor activation by reversible dimerization on living cells

29 May 2018

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29 May 2018

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Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

An ultrasensitive sorting mechanism for EGF receptor endocytosis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system

29 May 2018

1 reference

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Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Mechanisms for oncogenic activation of the epidermal growth factor receptor

29 May 2018

1 reference

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Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

29 May 2018

1 reference

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Epidermal growth factor receptor mutations in lung cancer

29 May 2018

1 reference

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

29 May 2018

1 reference

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A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

29 May 2018

1 reference

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EGF-ERBB signalling: towards the systems level

29 May 2018

1 reference

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

29 May 2018

1 reference

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Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

29 May 2018

1 reference

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Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

29 May 2018

1 reference

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The Cbl interactome and its functions

29 May 2018

1 reference

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Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants

29 May 2018

1 reference

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Clathrin-independent endocytosis of ubiquitinated cargos

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

A structure-based model for ligand binding and dimerization of EGF receptors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

An integrated model of epidermal growth factor receptor trafficking and signal transduction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Grb2 regulates internalization of EGF receptors through clathrin-coated pits

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Epidermal growth factor receptor dependence in human tumors: more than just expression?

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Cell signaling by receptor tyrosine kinases

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538861

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8999

Exact stochastic simulation of coupled chemical reactions

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8999

21 January 2018

Identifiers

DOI

10.1038/NCOMMS8999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264748%20AND%20SRC:MED&resulttype=core&format=json