(Q42142796)

17 October 2017

DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs? (English)

1 reference

17 October 2017

Workman P

1

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17 October 2017

Walton MI

series ordinal

2

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17 October 2017

Powis G

series ordinal

3

1 reference

17 October 2017

Schlager JJ

series ordinal

4

1 reference

17 October 2017

language of work or name

English

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publication date

1 November 1989

1 reference

British Journal of Cancer

17 October 2017

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17 October 2017

60

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17 October 2017

5

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17 October 2017

800-2; discussion 803

1 reference

https://scigraph.springernature.com/pub.10.1038/bjc.1989.364

17 October 2017

0 references

cites work

Walker carcinosarcoma 256 in study of anticancer agents. I. Method for simultaneous assessment of therapeutic value and toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

Structure and regulation of glutathione S-transferase genes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2247312

One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

29 May 2018

1 reference

12 December 2020

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

1 reference

12 December 2020

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells

1 reference

12 December 2020

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase

1 reference

12 December 2020

Induction of dna damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes

1 reference

12 December 2020

Adriamycin and DT-diaphorase

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12 December 2020

Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics

1 reference

12 December 2020

Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA

1 reference

12 December 2020

1 reference

12 December 2020

Reductive activation of mitomycin C

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12 December 2020

Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation

1 reference

12 December 2020

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

1 reference

12 December 2020

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1989.364

1 reference

17 October 2017

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17 October 2017

PubMed publication ID

2508739

1 reference