(Q42166429)

17 October 2017

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules (English)

1 reference

17 October 2017

Laura A Banaszynski

1

1 reference

17 October 2017

Ling-Chun Chen

2

1 reference

17 October 2017

Lystranne A Maynard-Smith

3

1 reference

17 October 2017

A G Lisa Ooi

4

1 reference

17 October 2017

Thomas J Wandless

5

1 reference

17 October 2017

language of work or name

English

0 references

publication date

1 September 2006

1 reference

17 October 2017

1 reference

17 October 2017

126

1 reference

17 October 2017

5

1 reference

17 October 2017

995-1004

1 reference

Conditional control of protein function

17 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Optimizing RNA interference for application in mammalian cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Chemical genetic control of protein levels: selective in vivo targeted degradation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Back to the future with ubiquitin

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Regulating cell surface glycosylation by small molecule control of enzyme localization

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

The specificities of protein kinase inhibitors: an update

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Dimerizer-regulated gene expression

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Conditional transgenic technologies

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Mitotic kinases as regulators of cell division and its checkpoints

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Impairment of the ubiquitin-proteasome system by protein aggregation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

A chemical switch for inhibitor-sensitive alleles of any protein kinase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Specificity and mechanism of action of some commonly used protein kinase inhibitors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Uninterrupted MCM2-7 function required for DNA replication fork progression

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Attenuation of green fluorescent protein half-life in mammalian cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

In vivo half-life of a protein is a function of its amino-terminal residue

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

A strategy for the generation of conditional mutations by protein destabilization

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Switch-of-Function Mutants Based on Morphology Classification of Ras Superfamily Small GTPases

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Design of allele-specific inhibitors to probe protein kinase signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

A chemical-genetic approach to studying neurotrophin signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Dynamics of gene silencing by RNA interference.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Localization to the proteasome is sufficient for degradation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Conditional protein alleles using knockin mice and a chemical inducer of dimerization

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Heat-inducible degron: a method for constructing temperature-sensitive mutants.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290523

Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16959577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16959577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2006.07.025

1 reference

release_lx2ztcyyrbghza22lnp7sgsiqu

17 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lx2ztcyyrbghza22lnp7sgsiqu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

17 October 2017

PubMed publication ID

16959577

1 reference