(Q42166581)

English

1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide

scientific article published on April 2003

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scholarly article

1 reference

Europe PubMed Central

17 October 2017

1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide (English)

1 reference

Europe PubMed Central

17 October 2017

1 reference

ChEBI release 2020-05-28

author name string

Shasi V Kalivendi

1

1 reference

Europe PubMed Central

17 October 2017

Srigiridhar Kotamraju

2

1 reference

Europe PubMed Central

17 October 2017

Sonya Cunningham

3

1 reference

Europe PubMed Central

17 October 2017

Tiesong Shang

4

1 reference

Europe PubMed Central

17 October 2017

Cecilia J Hillard

5

1 reference

Europe PubMed Central

17 October 2017

B Kalyanaraman

6

1 reference

Europe PubMed Central

17 October 2017

language of work or name

0 references

publication date

1 April 2003

1 reference

Europe PubMed Central

17 October 2017

number of pages

14

1 reference

based on heuristic

inferred from page(s)

Biochemical Journal

1 reference

Europe PubMed Central

17 October 2017

371

1 reference

Europe PubMed Central

17 October 2017

Pt 1

1 reference

Europe PubMed Central

17 October 2017

151-164

1 reference

Europe PubMed Central

17 October 2017

Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Multifunctional antioxidant activity of HBED iron chelator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

The possible role of iron in the etiopathology of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

26 October 2017

The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Superoxide dismutase. Organelle specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Superoxide sensitivity of the Escherichia coli aconitase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

29 May 2018

Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

Effect of mitochondrial electron transport chain inhibitors on superoxide radical generation in rat hippocampal and striatal slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223270

17 August 2018

The role of the mitochondrion in cellular iron homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of the iron chelator desferrioxamine against MPP+ toxicity on striatal dopaminergic terminals

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MPP+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of iron in the activation-inactivation of aconitase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of free radicals in MPP+ neurotoxicity against rat dopaminergic neurons in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress indicators are elevated in de novo Parkinson's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of growth inhibition by anti-transferrin receptor monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12523938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20021525

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

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