(Q42200165)

18 October 2017

title

Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses (English)

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18 October 2017

Diana F Florescu

1

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18 October 2017

Megan A Keck

series ordinal

2

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18 October 2017

publication date

13 August 2014

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Expert Review of Anti-infective Therapy

18 October 2017

published in

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18 October 2017

volume

12

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18 October 2017

issue

10

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18 October 2017

page(s)

1171-1178

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The eradication of smallpox--an overview of the past, present, and future

18 October 2017

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Treatment of Vaccinia and Cowpox Virus Infections in Mice with CMX001 and ST-246.

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Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.

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Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro

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Development of CMX001 for the Treatment of Poxvirus Infections

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Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.

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Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir

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Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies

21 January 2018

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21 January 2018

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Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).

21 January 2018

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Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

21 January 2018

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First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses

21 January 2018

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CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation

21 January 2018

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Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro

21 January 2018

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Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus

21 January 2018

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Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

21 January 2018

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Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection

21 January 2018

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Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis

21 January 2018

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Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients

21 January 2018

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Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication

21 January 2018

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Reconstitution of simian virus 40 DNA replication with purified proteins

21 January 2018

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Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system

21 January 2018

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Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression

21 January 2018

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1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells

21 January 2018

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Hexadecyloxypropyl-Cidofovir (CMX001) Suppresses JC Virus Replication in Human Fetal Brain SVG Cell Cultures

21 January 2018

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CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes

21 January 2018

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A case of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia

21 January 2018

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Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.2014.948847

Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14787210.2014.948847

10.1586/14787210.2014.948847

21 January 2018

Identifiers

DOI

1 reference

18 October 2017

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