(Q42211301)

English

Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells

scientific article published on 3 May 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells (English)

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

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author name string

Makoto Osada

1

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Osamu Inoue

2

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Guo Ding

3

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Toshiaki Shirai

4

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Hirotake Ichise

5

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Kazuyoshi Hirayama

6

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Katsuhiro Takano

7

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Yutaka Yatomi

8

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Masanori Hirashima

9

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Hideki Fujii

10

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Katsue Suzuki-Inoue

11

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Yukio Ozaki

12

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

language of work or name

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publication date

3 May 2012

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

18 October 2017

287

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Europe PubMed Central

PMC publication ID

18 October 2017

26

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Europe PubMed Central

PMC publication ID

18 October 2017

22241-22252

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3381185/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

How platelets safeguard vascular integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

A mouse knockout library for secreted and transmembrane proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Bone morphogenetic protein receptors and signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Platelet aggregation in the formation of tumor metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Integrins in angiogenesis and lymphangiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Kindlin-3 is essential for integrin activation and platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Renal cells activate the platelet receptor CLEC-2 through podoplanin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Influence of angiostatin and thalidomide on lymphangiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Bone morphogenetic protein-9. An autocrine/paracrine cytokine in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Evidence that platelets promote tube formation by endothelial cells on matrigel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Bone morphogenetic protein receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Bone morphogenetic proteins: multifunctional regulators of vertebrate development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

The bone morphogenetic protein family and osteogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

26 October 2017

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

29 May 2018

Mitochondrial reactive oxygen species: a common pathway for PAR1- and PAR2-mediated tissue factor induction in human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

29 May 2018

Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (Malayan pit viper), stimulates platelets by binding to α2β1 integrin and glycoprotein Ib, activating Syk and phospholipase Cγ 2, but does not involve the glycoprotein VI/Fc recept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

29 May 2018

A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C‐type lectin protein, through CLEC‐2 ligation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

17 August 2018

H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

17 August 2018

Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

17 August 2018

Influence of angiogenesis inhibitors, endostatin and PF-4, on lymphangiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

17 August 2018

Platelet-released supernatant increases matrix metalloproteinase-2 production, migration, proliferation, and tube formation of human umbilical vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

17 August 2018

Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381185

17 August 2018

Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22556408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22556408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22556408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22556408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42

1 reference

https://pubmed.ncbi.nlm.nih.gov/22556408

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.329987

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

release_gn2bik6cpjbq3gu3uotrz2lt7q

1 reference

https://api.fatcat.wiki/v0/release/gn2bik6cpjbq3gu3uotrz2lt7q

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

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