(Q4223101)

Clusterin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Clusterin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Clusterin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

Parkinsons Disease Gene Ontology Initiative

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

misfolded protein binding

ISS

ATPase activity

1 reference

3 January 2017

Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

protein binding

8 references

3 January 2017

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

ERp57 is essential for efficient folding of glycoproteins sharing common structural domains

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

PACAP inhibits tumor growth and interferes with clusterin in cervical carcinomas

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

A comprehensive resource of interacting protein regions for refining human transcription factor networks

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Clusterin inhibits apoptosis by interacting with activated Bax

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

ubiquitin protein ligase binding

1 reference

3 January 2017

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

cell component

apical dendrite

1 reference

3 January 2017

Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

cytosol

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

Golgi apparatus

Parkinsons Disease Gene Ontology Initiative

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

ISS

blood microparticle

1 reference

3 January 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

mitochondrial membranes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

neurofibrillary tangle

chromaffin granule

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

spherical high-density lipoprotein particle

1 reference

3 January 2017

Isolation and characterization of human apolipoprotein M-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

extracellular region

2 references

cell surface

1 reference

3 January 2017

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

extracellular exosome

4 references

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

platelet alpha granule lumen

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

nucleus

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

intracellular anatomical structure

1 reference

3 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

perinuclear region of cytoplasm

1 reference

3 January 2017

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

extracellular space

Ensembl genome database project

7 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Characterization of an eppin protein complex from human semen and spermatozoa

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Identification of human plasma proteins as major clients for the extracellular chaperone clusterin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Clusterin inhibits apoptosis by interacting with activated Bax

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

biological process

apoptotic process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

central nervous system myelin maintenance

1 reference

3 January 2017

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

negative regulation of protein homooligomerization

1 reference

3 January 2017

Clusterin inhibits apoptosis by interacting with activated Bax

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

response to misfolded protein

1 reference

3 January 2017

Identification of human plasma proteins as major clients for the extracellular chaperone clusterin

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

chaperone-mediated protein complex assembly

1 reference

3 January 2017

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

positive regulation of tau-protein kinase activity

1 reference

3 January 2017

Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

lipid metabolism

NAS

1 reference

3 January 2017

Purification and characterization of apolipoprotein J

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

NAS

immune system process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

negative regulation of amyloid-beta formation

positive regulation of nitric oxide biosynthetic process

1 reference

3 January 2017

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

complement activation

1 reference

3 January 2017

Clusterin: the intriguing guises of a widely expressed glycoprotein

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

response to virus

IEP

1 reference

3 January 2017

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

IEP

protein stabilization

1 reference

3 January 2017

Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

platelet degranulation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

positive regulation of neuron death

Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain

3 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

Ensembl genome database project

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

3 January 2017

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

3 January 2017

Clusterin inhibits apoptosis by interacting with activated Bax

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

positive regulation of neurofibrillary tangle assembly

1 reference

3 January 2017

Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

microglial cell activation

1 reference

3 January 2017

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

protein import

1 reference

3 January 2017

Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

intrinsic apoptotic signaling pathway

1 reference

3 January 2017

Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

regulation of neuronal signal transduction

1 reference

3 January 2017

Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

microglial cell proliferation

1 reference

3 January 2017

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

positive regulation of NF-kappaB transcription factor activity

1 reference

3 January 2017

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

3 January 2017

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

cell morphogenesis

1 reference

3 January 2017

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

regulation of neuron death

complement activation, classical pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

positive regulation of tumor necrosis factor production

1 reference

3 January 2017

Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

positive regulation of apoptotic process

1 reference

3 January 2017

Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

regulation of amyloid-beta clearance

1 reference

3 January 2017

Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

innate immune response

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

positive regulation of intrinsic apoptotic signaling pathway

1 reference

3 January 2017

Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

3 January 2017

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

release of cytochrome c from mitochondria

IC

1 reference

3 January 2017

Clusterin inhibits apoptosis by interacting with activated Bax

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

reverse cholesterol transport

IC

1 reference

3 January 2017

Isolation and characterization of human apolipoprotein M-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

chaperone-mediated protein folding

1 reference

3 January 2017

Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

antimicrobial humoral response

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10909

1 reference

3 January 2017

has part(s)

Clusterin, N-terminal

1 reference

Clusterin, C-terminal

1 reference

Clusterin, conserved site

1 reference