(Q42248604)

English

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.

scientific article published on 7 July 2015

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152715%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages (English)

1 reference

Europe PubMed Central

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18 February 2020

lipopolysaccharide

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1 reference

based on heuristic

inferred from title

reactive oxygen species

1 reference

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Michael P. Murphy

3

1 reference

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18 February 2020

Luke A. J. O'Neill

4

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18 February 2020

author name string

Beth Kelly

1

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18 February 2020

Gillian M Tannahill

2

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18 February 2020

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publication date

7 July 2015

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18 February 2020

number of pages

12

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inferred from page(s)

Journal of Biological Chemistry

1 reference

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18 February 2020

290

1 reference

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18 February 2020

33

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18 February 2020

20348-20359

1 reference

Europe PubMed Central

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18 February 2020

Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

1 reference

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26 October 2017

Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction.

1 reference

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26 October 2017

Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity

1 reference

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AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury

1 reference

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26 October 2017

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

1 reference

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1 reference

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Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.

1 reference

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AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

1 reference

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Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

1 reference

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26 October 2017

Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.

1 reference

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26 October 2017

The ancient drug salicylate directly activates AMP-activated protein kinase

1 reference

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

1 reference

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26 October 2017

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Type 2 diabetes as an inflammatory disease

1 reference

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26 October 2017

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

1 reference

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26 October 2017

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

AMPK: Lessons from transgenic and knockout animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

How mitochondria produce reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

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Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

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A central role for JNK in obesity and insulin resistance

1 reference

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Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle

1 reference

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26 October 2017

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Mechanism by which metformin reduces glucose production in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536441

26 October 2017

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

1 reference

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

1 reference

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The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

1 reference

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Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

1 reference

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12 December 2020

based on heuristic

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The interaction of energy and electron transfer reactions in mitochondria. I. General properties and nature of the products of succinate-linked reduction of pyridine nucleotide

1 reference

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The interaction of energy and electron transfer reactions in mitochondria. IV. The pathway of electron transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26152715

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based on heuristic

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Identifiers

10.1074/JBC.M115.662114

1 reference

Europe PubMed Central

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18 February 2020

1 reference

Europe PubMed Central

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18 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152715%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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