(Q42276602)

English

Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer's disease model

scientific article published on 19 August 2013

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scholarly article

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Europe PubMed Central

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7 March 2020

Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer's disease model (English)

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7 March 2020

Alzheimer's disease

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inferred from title

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7 March 2020

author name string

Ofra Ben-Menachem-Zidon

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7 March 2020

Yair Ben-Menahem

2

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7 March 2020

Tamir Ben-Hur

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7 March 2020

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19 August 2013

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7 March 2020

Neuropsychopharmacology

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7 March 2020

39

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7 March 2020

2

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7 March 2020

401-414

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Europe PubMed Central

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7 March 2020

https://scigraph.springernature.com/pub.10.1038/npp.2013.208

0 references

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1 reference

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Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model

1 reference

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26 October 2017

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

1 reference

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26 October 2017

Concise review: Can stem cells be used to treat or model Alzheimer's disease?

1 reference

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26 October 2017

Modulation of murine Alzheimer pathogenesis and behavior by surgery

1 reference

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26 October 2017

Microglia in Alzheimer's Disease: It's All About Context

1 reference

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26 October 2017

Microglia as modulators of cognition and neuropsychiatric disorders

1 reference

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26 October 2017

Analysis of differential plaque depositions in the brains of Tg2576 and Tg-APPswe/PS1dE9 transgenic mouse models of Alzheimer disease

1 reference

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26 October 2017

Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Adult hippocampal neurogenesis and its role in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Alzheimer's - Looking beyond plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Immune modulation of learning, memory, neural plasticity and neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Neuroinflammatory processes in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

The role of microglia in amyloid clearance from the AD brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Neurogenesis in the aged and neurodegenerative brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Mechanisms underlying inflammation in neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

The multifaceted profile of activated microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Interleukin-1 (IL-1): a central regulator of stress responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Evidence for a cytokine model of cognitive function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Brain inflammation and adult neurogenesis: the dual role of microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

1 reference

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26 October 2017

IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress

1 reference

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26 October 2017

Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production

1 reference

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26 October 2017

Studies on brain volume, Alzheimer-related proteins and cytokines in mice with chronic overexpression of IL-1 receptor antagonist

1 reference

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26 October 2017

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

1 reference

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26 October 2017

Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment.

1 reference

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26 October 2017

Interleukin-1 and neuronal injury

1 reference

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26 October 2017

Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Inflammatory processes in Alzheimer's disease

1 reference

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26 October 2017

Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

1 reference

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26 October 2017

The immune system and memory consolidation: a role for the cytokine IL-1beta.

1 reference

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26 October 2017

Inflammation and Alzheimer's disease

1 reference

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26 October 2017

Genetic influence on neurogenesis in the dentate gyrus of adult mice

1 reference

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26 October 2017

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

1 reference

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26 October 2017

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

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26 October 2017

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

26 October 2017

Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

29 May 2018

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist.

1 reference

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29 May 2018

Time limited immunomodulatory functions of transplanted neural precursor cells.

1 reference

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17 August 2018

Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement

1 reference

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17 August 2018

Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

17 August 2018

Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

17 August 2018

Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

17 August 2018

Association between the interleukin-1alpha gene and Alzheimer's disease: a meta-analysis

1 reference

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17 August 2018

BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

17 August 2018

Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

17 August 2018

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870779

17 August 2018

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/23954849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23954849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/NPP.2013.208

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954849%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Dimensions Publication ID

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1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954849%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954849%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

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